8JU6
Structure of human TRPV4 with antagonist GSK279
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2568 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | MET1-VAL469 | |
D | LYS535-GLY547 | |
D | ARG594-LYS608 | |
D | GLY723-LEU871 | |
C | MET1-VAL469 | |
C | LYS535-GLY547 | |
C | ARG594-LYS608 | |
C | GLY723-LEU871 | |
A | LYS535-GLY547 | |
A | ARG594-LYS608 | |
A | GLY723-LEU871 | |
B | MET1-VAL469 | |
B | LYS535-GLY547 | |
B | ARG594-LYS608 | |
B | GLY723-LEU871 | |
D | MET1-VAL469 |
site_id | SWS_FT_FI2 |
Number of Residues | 564 |
Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER470-TYR490 | |
B | ALA573-THR593 | |
B | ILE609-LEU636 | |
B | VAL694-VAL722 | |
D | SER470-TYR490 | |
D | TYR508-MET534 | |
D | SER548-LEU568 | |
D | ALA573-THR593 | |
D | ILE609-LEU636 | |
D | VAL694-VAL722 | |
C | SER470-TYR490 | |
A | TYR508-MET534 | |
C | TYR508-MET534 | |
C | SER548-LEU568 | |
C | ALA573-THR593 | |
C | ILE609-LEU636 | |
C | VAL694-VAL722 | |
A | SER548-LEU568 | |
A | ALA573-THR593 | |
A | ILE609-LEU636 | |
A | VAL694-VAL722 | |
B | SER470-TYR490 | |
B | TYR508-MET534 | |
B | SER548-LEU568 |
site_id | SWS_FT_FI3 |
Number of Residues | 216 |
Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | TYR491-ASP507 | |
D | ALA569-GLU572 | |
D | ASN637-THR665 | |
D | LEU686-VAL693 | |
C | TYR491-ASP507 | |
C | ALA569-GLU572 | |
C | ASN637-THR665 | |
C | LEU686-VAL693 | |
A | ALA569-GLU572 | |
A | ASN637-THR665 | |
A | LEU686-VAL693 | |
B | TYR491-ASP507 | |
B | ALA569-GLU572 | |
B | ASN637-THR665 | |
B | LEU686-VAL693 | |
D | TYR491-ASP507 |
site_id | SWS_FT_FI4 |
Number of Residues | 76 |
Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | PHE666-MET685 | |
B | PHE666-MET685 | |
D | PHE666-MET685 | |
C | PHE666-MET685 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22702953, ECO:0007744|PDB:4DX2 |
Chain | Residue | Details |
A | LYS192 | |
B | ARG248 | |
D | LYS192 | |
D | LYS197 | |
D | ASN201 | |
D | TYR236 | |
D | ARG248 | |
C | LYS192 | |
C | LYS197 | |
C | ASN201 | |
C | TYR236 | |
A | LYS197 | |
C | ARG248 | |
A | ASN201 | |
A | TYR236 | |
A | ARG248 | |
B | LYS192 | |
B | LYS197 | |
B | ASN201 | |
B | TYR236 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:A0A1D5PXA5 |
Chain | Residue | Details |
A | ARG249 | |
C | ARG249 | |
C | ASN296 | |
C | LYS344 | |
A | ASN296 | |
A | LYS344 | |
B | ARG249 | |
B | ASN296 | |
B | LYS344 | |
D | ARG249 | |
D | ASN296 | |
D | LYS344 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
Chain | Residue | Details |
A | ASP682 | |
B | ASP682 | |
D | ASP682 | |
C | ASP682 |
site_id | SWS_FT_FI8 |
Number of Residues | 12 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9EPK8 |
Chain | Residue | Details |
A | TYR110 | |
C | TYR110 | |
C | TYR253 | |
C | TYR805 | |
A | TYR253 | |
A | TYR805 | |
B | TYR110 | |
B | TYR253 | |
B | TYR805 | |
D | TYR110 | |
D | TYR253 | |
D | TYR805 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9EPK8 |
Chain | Residue | Details |
A | SER824 | |
B | SER824 | |
D | SER824 | |
C | SER824 |