PDB: 52540 resultsInfo pagesStatus searchChemie searchBIRD

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8TL0	Structure of activated SAVED-CHAT filament Descriptor: CHAT domain-containing protein, RNA (5'-R(*AP*AP*A)-3') Authors: Bravo, J.P.K, Taylor, D.W. Deposit date: 2023-07-26 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Type III-B CRISPR-Cas cascade of proteolytic cleavages. Science, 383, 2024
6I2H	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190 Descriptor: CHLORIDE ION, UPF0418 protein FAM164A, [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2018-11-01 Release date: 2019-11-20 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190 To be published
6I2A	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp153 and Fasudil Descriptor: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, beta-D-ribopyranose, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2018-11-01 Release date: 2019-05-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6B34	NMR ensemble of Tyrocidine A analogue AC3.27 Descriptor: Tyrocidine A analogue D-PHE-BE2-PHE-D-PHE-ASN-GLN-TYR-VAL-ORN-LEU Authors: Cameron, A.J, Ewdards, P.J.B, Harjes, E, Sarojini, V. Deposit date: 2017-09-20 Release date: 2017-12-06 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity. J. Med. Chem., 60, 2017
6B35	NMR ensemble of Tyrocidine A analogue AC3.28 Descriptor: Tyrocidine A analogue D-PHE-BE2-PHE-D-PHE-ASN-LYS-TYR-VAL-ORN-LEU Authors: Cameron, A.J, Ewdards, P.J.B, Harjes, E, Sarojini, V. Deposit date: 2017-09-20 Release date: 2017-12-06 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity. J. Med. Chem., 60, 2017
6ZU5	Structure of the Paranosema locustae ribosome in complex with Lso2 Descriptor: 18S rRNA, 25S rRNA, 5S rRNA, ... Authors: Ehrenbolger, K, Jespersen, N, Sharma, H, Sokolova, Y.Y, Tokarev, Y.S, Vossbrinck, C.R, Barandun, J. Deposit date: 2020-07-21 Release date: 2020-11-04 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome. Plos Biol., 18, 2020
7BBJ	CD73 in complex with the humanized antagonistic antibody mAb19 Descriptor: 5'-nucleotidase, MAGNESIUM ION, ZINC ION, ... Authors: Boettcher, J, Han, F. Deposit date: 2020-12-17 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.72 Å) Cite: A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway. Mol.Cancer Ther., 20, 2021
6I2D	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp117 Descriptor: UPF0418 protein FAM164A, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, cAMP-dependent protein kinase catalytic subunit alpha Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2018-11-01 Release date: 2019-05-15 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6I2B	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp153 and RKp117 Descriptor: UPF0418 protein FAM164A, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, beta-D-ribopyranose, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2018-11-01 Release date: 2019-05-15 Last modified: 2021-03-17 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6I2C	Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and Fasudil Descriptor: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, beta-D-ribopyranose, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2018-11-01 Release date: 2019-05-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
5OT3	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp117 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-08-19 Release date: 2018-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
5OTG	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 and RKp190 Descriptor: [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-08-21 Release date: 2018-09-05 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 and RKp190 To be published
8DBK	Human PRPS1 with Phosphate, ATP, and R5P; Hexamer with resolved catalytic loops Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... Authors: Hvorecny, K.L, Kollman, J.M. Deposit date: 2022-06-14 Release date: 2023-02-15 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
5NTJ	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp032 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, beta-D-ribopyranose, cAMP-dependent protein kinase catalytic subunit alpha, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-04-28 Release date: 2018-05-30 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Crystal structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp032 To Be Published
5OUC	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp190 Descriptor: CHLORIDE ION, [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, beta-D-ribopyranose, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-08-23 Release date: 2018-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp190 To be published
5OUS	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp193 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-08-24 Release date: 2018-09-05 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
5OL3	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 and RKp117 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-07-26 Release date: 2018-08-29 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
4EQ4	Crystal structure of seleno-methionine derivatized GH3.12 Descriptor: 2-HYDROXYBENZOIC ACID, 4-substituted benzoates-glutamate ligase GH3.12, ADENOSINE MONOPHOSPHATE Authors: Zubieta, C, Nanao, M, Jez, J, Westfall, C, Kapp, U. Deposit date: 2012-04-18 Release date: 2012-06-20 Last modified: 2012-07-25 Method: X-RAY DIFFRACTION (2.074 Å) Cite: Structural basis for prereceptor modulation of plant hormones by GH3 proteins. Science, 336, 2012
5O5M	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp117 Descriptor: CHLORIDE ION, RKp120, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-06-02 Release date: 2018-06-13 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (1.583 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
5O0E	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and Fasudil Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, RKp120, ... Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-05-16 Release date: 2018-05-30 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
8FZD	Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B) Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... Authors: Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G. Deposit date: 2023-01-28 Release date: 2024-07-17 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The ribosome termination complex remodels release factor RF3 and ejects GDP. Nat.Struct.Mol.Biol., 2024
8IK0	Cryo-EM structure of Stimulator of interferon genes Descriptor: Stimulator of interferon genes protein,Immune protein Tsi3 Authors: Lu, D.F, Shang, G.J. Deposit date: 2023-02-28 Release date: 2023-05-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The mechanism of STING autoinhibition and activation. Mol.Cell, 83, 2023
5OUA	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp017 Descriptor: beta-D-ribopyranose, cAMP dependent protein kinase inhibitor, cAMP-dependent protein kinase catalytic subunit alpha Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-08-23 Release date: 2018-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
2MCX	Solid-state NMR structure of piscidin 3 in aligned 1:1 phosphatidylethanolamine/phosphoglycerol lipid bilayers Descriptor: Piscidin-3 Authors: Fu, R, Tian, Y, Perrin Jr, B.S, Grant, C.V, Wieczorek, W.E, Pastor, R.W, Cotten, M.L. Deposit date: 2013-08-27 Release date: 2014-01-22 Last modified: 2021-08-18 Method: SOLID-STATE NMR Cite: High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion. J.Am.Chem.Soc., 136, 2014
5OK3	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp241 and Fasudil Descriptor: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, cAMP-dependent protein kinase catalytic subunit alpha Authors: Mueller, J.M, Heine, A, Klebe, G. Deposit date: 2017-07-25 Release date: 2018-08-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.588 Å) Cite: Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues. Chemmedchem, 14, 2019

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