6I2C

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and Fasudil

Replaces:  6ERS

Summary for 6I2C

DescriptorcAMP-dependent protein kinase catalytic subunit alpha, UPF0418 protein FAM164A, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ... (5 entities in total)
Functional Keywordscomplex, peptidic ligand, transferase
Biological sourceCricetulus griseus (Chinese hamster)
Total number of polymer chains2
Total molecular weight43639.43
Authors
Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2018-11-01, release date: 2019-05-15)
Primary citation
Mueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G.
Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage
Acs Omega, 2019
DOI: 10.1021/acsomega.8b02364
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22300 0.7% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6i2c
no rotation
Molmil generated image of 6i2c
rotated about x axis by 90°
Molmil generated image of 6i2c
rotated about y axis by 90°