6I2C
Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and Fasudil
Replaces: 6ERSEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41193.7 | 1 | UniProt (P25321) Pfam (PF00069) In PDB | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B | UPF0418 protein FAM164A | polymer | 18 | 2004.2 | 1 | UniProt (G3HK48) In PDB | Cricetulus griseus | |
| 3 | A | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | non-polymer | 291.4 | 1 | Chemie (M77) | |||
| 4 | B | beta-D-ribopyranose | non-polymer | 150.1 | 1 | Chemie (RIP) | |||
| 5 | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
B: 11 - 28 (UniProt: G3HK48)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| His -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 23 | Gly 18 | conflict |
| Asp 26 | Asn 21 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43197.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 441.5 | |
| All* | Total formula weight | 43639.4 |
