6I2D

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp117

Replaces:  6EMD

Summary for 6I2D

• Entry DOI: 10.2210/pdb6i2d/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, UPF0418 protein FAM164A, [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, ... (4 entities in total)
• Functional Keywords: complex, peptidic ligand, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43623.24

Authors

Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2018-11-01, release date: 2019-05-15)

• Primary citation: Mueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G.; Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage; Acs Omega, 2019; DOI: 10.1021/acsomega.8b02364

Experimental method

X-RAY DIFFRACTION (1.91 Å)