6I2D

Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp117

Replaces:  6EMD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cAMP-dependent protein kinase catalytic subunit alpha	polymer	353	41193.7	1	UniProt (P25321) Pfam (PF00069) In PDB	Cricetulus griseus (Chinese hamster)	PKA C-alpha
2	D	UPF0418 protein FAM164A	polymer	18	2004.2	1	UniProt (G3HK48) In PDB	Cricetulus griseus
3	A	[2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid	non-polymer		425.3	1	Chemie (9LQ)
4		water	water		18.0	111	Chemie (HOH)

Sequence modifications

A: 0 - 350 (UniProt: P25321)

PDB	External Database	Details
Gly -2	-	expression tag
His -1	-	expression tag

D: 8 - 25 (UniProt: G3HK48)

PDB	External Database	Details
Ser 20	Gly 18	conflict
Asp 23	Asn 21	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43197.9
Non-Polymers*	Number of molecules	1
	Total formula weight	425.3
All*	Total formula weight	43623.2

*Water molecules are not included.