5O0E

Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and Fasudil

Summary for 5O0E

Entry DOI	10.2210/pdb5o0e/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, RKp120, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ... (5 entities in total)
Functional Keywords	complex, peptidic ligand, ribose, transferase
Biological source	Cricetulus griseus (Chinese hamster) More
Total number of polymer chains	2
Total formula weight	43549.44
Authors	Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2017-05-16, release date: 2018-05-30, Last modification date: 2024-10-23)
Primary citation	Mueller, J.M.,Kirschner, R.,Geyer, A.,Klebe, G. Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019 Cited by DOI: 10.1021/acsomega.8b02364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation