5OUC

Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp190

Summary for 5OUC

DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor, [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, ... (6 entities in total)
Functional Keywordscomplex, peptidic ligand, transferase
Biological sourceCricetulus griseus (Chinese hamster)
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Total number of polymer chains2
Total molecular weight43753.75
Authors
Mueller, J.M.,Heine, A.,Klebe, G. (deposition date: 2017-08-23, release date: 2018-09-05)
Primary citation
Mueller, J.M.,Kirschner, R.,Heine, A.,Geyer, A.,Klebe, G.
Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp191 and RKp190
To be published,
Experimental method
X-RAY DIFFRACTION (1.46 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1771006.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution