2UY7
| Crystal structure of the P pilus rod subunit PapA | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN, PERIPLASMID CHAPERONE PAPD PROTEIN, SULFATE ION | Authors: | Verger, D, Bullitt, E, Hultgren, S.J, Waksman, G. | Deposit date: | 2007-04-02 | Release date: | 2007-05-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the P Pilus Rod Subunit Papa. Plos Pathog., 3, 2007
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2WMP
| Structure of the E. coli chaperone PapD in complex with the pilin domain of the PapGII adhesin | Descriptor: | CHAPERONE PROTEIN PAPD, PAPG PROTEIN | Authors: | Ford, B.A, Verger, D, Elam, J.S, Dodson, K.W, Pinkner, J.S, Hultgren, S.J. | Deposit date: | 2009-07-02 | Release date: | 2010-08-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Papd-Papgii Pilin Complex Reveals an Open and Flexible P5 Pocket. J.Bacteriol., 194, 2012
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2OS7
| Caf1M periplasmic chaperone tetramer | Descriptor: | Chaperone protein caf1M | Authors: | Knight, S.D, Zavialov, A.Z. | Deposit date: | 2007-02-05 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A novel self-capping mechanism controls aggregation of periplasmic chaperone Caf1M MOL.MICROBIOL., 64, 2007
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2XAC
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5ZQT
| Crystal structure of Oryza sativa hexokinase 6 | Descriptor: | Hexokinase-6, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Matsudaira, K, Mochizuki, S, Yoshida, H, Kamitori, S, Akimitsu, K. | Deposit date: | 2018-04-20 | Release date: | 2019-04-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Crystal structure of Oryza sativa hexokinase 6 To Be Published
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4MLE
| Human Glucokinase in Complex with Novel Amino Thiazole Activator | Descriptor: | 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose | Authors: | Voegtli, W.C. | Deposit date: | 2013-09-06 | Release date: | 2013-09-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
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4MLH
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4NO7
| Human Glucokinase in complex with a nanomolar activator. | Descriptor: | (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide, Glucokinase, alpha-D-glucopyranose | Authors: | Petit, P, Ferry, G, Antoine, M, Boutin, J.A, Kotschy, A, Perron-Sierra, F, Mamelli, L, Vuillard, L. | Deposit date: | 2013-11-19 | Release date: | 2014-10-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr. D Biol. Crystallogr., 67, 2011
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4EEE
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1DGK
| MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, PHOSPHATE ION, ... | Authors: | Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. | Deposit date: | 1999-11-24 | Release date: | 2000-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
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4EKX
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4FPA
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6BFT
| Structure of Bevacizumab Fab mutant in complex with VEGF | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ... | Authors: | Christie, M, Christ, D. | Deposit date: | 2017-10-27 | Release date: | 2018-10-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Stable human IgG antibody therapeutics with native
framework structure To Be Published
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4GAF
| Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... | Authors: | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | Deposit date: | 2012-07-25 | Release date: | 2013-02-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
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5V4W
| Human glucokinase in complex with novel indazole activator. | Descriptor: | (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide, Glucokinase, IODIDE ION, ... | Authors: | Skene, R.J, Hosfield, D.J. | Deposit date: | 2017-03-10 | Release date: | 2017-05-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorg. Med. Chem. Lett., 27, 2017
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6CD2
| Crystal structure of the PapC usher bound to the chaperone-adhesin PapD-PapG | Descriptor: | Chaperone protein PapD, Outer membrane usher protein PapC, PapGII adhesin protein | Authors: | Omattage, N.S, Deng, Z, Yuan, P, Hultgren, S.J. | Deposit date: | 2018-02-07 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli. Nat Microbiol, 3, 2018
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1FLT
| VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR | Descriptor: | FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR | Authors: | Wiesmann, C, De Vos, A.M. | Deposit date: | 1997-11-20 | Release date: | 1999-01-13 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell(Cambridge,Mass.), 91, 1997
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4F9O
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4FOI
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4FPB
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1CZA
| MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, ... | Authors: | Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. | Deposit date: | 1999-09-01 | Release date: | 2000-03-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
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4FOE
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5V4X
| Human glucokinase in complex with novel pyrazole activator. | Descriptor: | (2S)-3-cyclohexyl-2-[4-(cyclopentylsulfonyl)-2-oxopyridin-1(2H)-yl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... | Authors: | Skene, R.J, Hosfiled, D.J. | Deposit date: | 2017-03-10 | Release date: | 2017-05-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorg. Med. Chem. Lett., 27, 2017
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1N0L
| Crystal structure of the PapD chaperone (C-terminally 6x histidine-tagged) bound to the PapE pilus subunit (N-terminal-deleted) from uropathogenic E. coli | Descriptor: | Chaperone protein PapD, mature Fimbrial protein PapE | Authors: | Sauer, F.G, Pinkner, J.S, Waksman, G, Hultgren, S.J. | Deposit date: | 2002-10-14 | Release date: | 2002-12-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation Cell(Cambridge,Mass.), 111, 2002
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1P5V
| X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex | Descriptor: | Chaperone protein Caf1M, F1 capsule antigen | Authors: | Zavialov, A.V, Berglund, J, Pudney, A.F, Fooks, L.J, Ibrahim, T.M, MacIntyre, S, Knight, S.D. | Deposit date: | 2003-04-28 | Release date: | 2003-06-24 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis. Preserved Folding Energy Drives Fiber Formation Cell(Cambridge,Mass.), 113, 2003
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