4NO7

Human Glucokinase in complex with a nanomolar activator.

Summary for 4NO7

• Entry DOI: 10.2210/pdb4no7/pdb
• Related: 1V4S 3ID8
• Descriptor: Glucokinase, alpha-D-glucopyranose, (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide, ... (4 entities in total)
• Functional Keywords: kinase, pancreas, transferase-transferase activator complex, transferase/transferase activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53598.24

Authors

Petit, P.,Ferry, G.,Antoine, M.,Boutin, J.A.,Kotschy, A.,Perron-Sierra, F.,Mamelli, L.,Vuillard, L. (deposition date: 2013-11-19, release date: 2014-10-29, Last modification date: 2023-09-20)

• Primary citation: Petit, P.,Antoine, M.,Ferry, G.,Boutin, J.A.,Lagarde, A.,Gluais, L.,Vincentelli, R.,Vuillard, L.; The active conformation of human glucokinase is not altered by allosteric activators.; Acta Crystallogr. D Biol. Crystallogr., 67:929-935, 2011; PubMed: 22101819; DOI: 10.1107/S0907444911036729

Experimental method

X-RAY DIFFRACTION (1.7 Å)