4NO7
Human Glucokinase in complex with a nanomolar activator.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucokinase | polymer | 470 | 52996.2 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB | Homo sapiens (human) | Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
2 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
3 | A | (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide | non-polymer | 421.9 | 1 | Chemie (2N8) | |||
4 | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence modifications
A: 12 - 465 (UniProt: P35557)
PDB | External Database | Details |
---|---|---|
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
Glu 4 | - | expression tag |
Asn 5 | - | expression tag |
Leu 6 | - | expression tag |
Tyr 7 | - | expression tag |
Phe 8 | - | expression tag |
Gln 9 | - | expression tag |
Gly 10 | - | expression tag |
Met 11 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 52996.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 602.1 | |
All* | Total formula weight | 53598.2 |