5V4W
Human glucokinase in complex with novel indazole activator.
Summary for 5V4W
| Entry DOI | 10.2210/pdb5v4w/pdb |
| Related | 5V4X |
| Descriptor | Glucokinase, alpha-D-glucopyranose, (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide, ... (5 entities in total) |
| Functional Keywords | activator, complex, allosteric, transferase-transferase activator complex, transferase/transferase activator |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 52160.95 |
| Authors | Skene, R.J.,Hosfield, D.J. (deposition date: 2017-03-10, release date: 2017-05-31, Last modification date: 2024-03-06) |
| Primary citation | Cheruvallath, Z.S.,Gwaltney, S.L.,Sabat, M.,Tang, M.,Wang, H.,Jennings, A.,Hosfield, D.,Lee, B.,Wu, Y.,Halkowycz, P.,Grimshaw, C.E. Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorg. Med. Chem. Lett., 27:2678-2682, 2017 Cited by PubMed: 28512030DOI: 10.1016/j.bmcl.2017.04.041 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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