5V4W
Human glucokinase in complex with novel indazole activator.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucokinase | polymer | 458 | 51375.3 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB | Homo sapiens (Human) | Hexokinase type IV,HK IV,Hexokinase-4,HK4,Hexokinase-D |
2 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
3 | A | (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide | non-polymer | 478.6 | 1 | Chemie (8WM) | |||
4 | A | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
5 | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 16 - 465 (UniProt: P35557)
PDB | External Database | Details |
---|---|---|
Met 8 | - | initiating methionine |
Leu 9 | - | expression tag |
Pro 10 | - | expression tag |
Gln 11 | - | expression tag |
Pro 12 | - | expression tag |
Asn 13 | - | expression tag |
Ser 14 | - | expression tag |
Gln 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51375.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 785.6 | |
All* | Total formula weight | 52160.9 |