PDB: 494 resultsInfo pagesStatus searchChemie searchBIRD

---

4U5L	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Descriptor: Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide Authors: Stewart, M, Valkov, E, Holvey, R.S. Deposit date: 2014-07-25 Release date: 2015-05-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
4U5S	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Descriptor: Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide Authors: Stewart, M, Valkov, E, Holvey, R.S. Deposit date: 2014-07-25 Release date: 2015-05-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
4U5U	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Descriptor: Importin subunit alpha-1, N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide Authors: Stewart, M, Valkov, E, Holvey, R.S. Deposit date: 2014-07-25 Release date: 2015-05-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
4U54	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Descriptor: Importin subunit alpha-1, N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine Authors: Stewart, M, Valkov, E, Holvey, R.S. Deposit date: 2014-07-24 Release date: 2015-05-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
4U58	IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR Descriptor: Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide Authors: Stewart, M, Valkov, E, Holvey, R.S. Deposit date: 2014-07-24 Release date: 2015-05-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
7RG1	Importin alpha2 in complex with MERS ORF4B H26A mutant Descriptor: Importin subunit alpha-1, ORF4b Authors: Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. Deposit date: 2021-07-14 Release date: 2021-07-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Importin alpha2 in complex with MERS ORF4B NLS H26A mutant To Be Published
2XWU	CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX Descriptor: IMPORTIN13, SUMO-CONJUGATING ENZYME UBC9 Authors: Gruenwald, M, Bono, F. Deposit date: 2010-11-05 Release date: 2010-12-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Importin13-Ubc9 Complex: Nuclear Import and Release of a Key Regulator of Sumoylation. Embo J., 30, 2011
3KND	TPX2:importin-alpha complex Descriptor: Importin subunit alpha-2, SULFATE ION, Targeting protein for Xklp2 Authors: Stewart, M. Deposit date: 2009-11-12 Release date: 2010-03-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.151 Å) Cite: Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha. J.Biol.Chem., 285, 2010
3L3Q	Mouse importin alpha-pepTM NLS peptide complex Descriptor: CITRATE ANION, Importin subunit alpha-2, pepTM Authors: Takeda, A.A.S, Kobe, B, Fontes, M.R.M. Deposit date: 2009-12-17 Release date: 2010-04-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. J.Biol.Chem., 285, 2010
8Q8K	KI Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-18 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
3RZX	Mouse importin alpha-Ku70 NLS peptide complex Descriptor: Importin subunit alpha-2, Ku70 NLS peptide Authors: Takeda, A.A.S, Fontes, M.R.M. Deposit date: 2011-05-12 Release date: 2011-08-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80. J.Mol.Biol., 412, 2011
3LWW	Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit Descriptor: Importin subunit beta-1, Snurportin-1 Authors: Bhardwaj, A, Cingolani, G. Deposit date: 2010-02-24 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. Biochemistry, 49, 2010
7UNK	Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex Descriptor: Histone H3, Histone H4, Histone chaperone, ... Authors: Bernardes, N.E, Chook, Y.M, Fung, H.Y.J, Chen, Z, Li, Y. Deposit date: 2022-04-11 Release date: 2022-09-21 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
5SVZ	HIV-1 Tat NLS in complex with importin alpha Descriptor: Importin subunit alpha-1, Tat Authors: Smith, K.M, Himiari, Z, Forwood, J.K. Deposit date: 2016-08-08 Release date: 2016-08-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Importin-alpha Binding of the Human Immunodeficiency Virus Tat. Sci Rep, 7, 2017
2C1M	Nup50:importin-alpha complex Descriptor: IMPORTIN-ALPHA2 SUBUNIT, NUCLEOPORIN 50 KDA Authors: Matsuura, Y, Stewart, M. Deposit date: 2005-09-16 Release date: 2005-11-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Nup50/Npap60 Function in Nuclear Protein Import Complex Disassembly and Importin Recycling. Embo J., 24, 2005
6IWA	Crystal structure of Importin-alpha and phosphoserine GM130 Descriptor: Importin subunit alpha-1, PHOSPHOSERINE GM130 Authors: Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. Deposit date: 2018-12-05 Release date: 2019-10-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
3ND2	Structure of Yeast Importin-beta (Kap95p) Descriptor: Importin subunit beta-1 Authors: Forwood, J.K, Kobe, B. Deposit date: 2010-06-06 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures Structure, 18, 2010
6IU7	Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type) Descriptor: Importin subunit alpha-1, Peptide from TP53-binding protein 1 Authors: Matsuura, Y. Deposit date: 2018-11-27 Release date: 2019-01-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochem. Biophys. Res. Commun., 510, 2019
1UKL	Crystal structure of Importin-beta and SREBP-2 complex Descriptor: Importin beta-1 subunit, Sterol regulatory element binding protein-2 Authors: Lee, S.J, Sekimoto, T, Yamashita, E, Nagoshi, E, Nakagawa, A, Imamoto, N, Yoshimura, M, Sakai, H, Tsukihara, T, Yoneda, Y. Deposit date: 2003-08-26 Release date: 2003-12-09 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3 Å) Cite: The Structure of Importin-beta Bound to SREBP-2: Nuclear Import of a Transcription Factor Science, 302, 2003
3OQS	Crystal structure of importin-alpha bound to a CLIC4 NLS peptide Descriptor: Importin subunit alpha-2, peptide of Chloride intracellular channel protein 4 Authors: Mynott, A.V, Brown, L.J, Harrop, S.J, Curmi, P.M.G. Deposit date: 2010-09-03 Release date: 2011-07-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 Febs J., 278, 2011
8DYO	Cryo-EM structure of Importin-4 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... Authors: Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. Deposit date: 2022-08-04 Release date: 2022-09-21 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (7.1 Å) Cite: Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
4XRK	Crystal Structure of Importin Beta in a Polyethylene Glycol Condition Descriptor: Importin Beta Authors: Tauchert, M.J, Neumann, P, Ficner, R, Dickmanns, A. Deposit date: 2015-01-21 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Impact of the crystallization condition on importin-beta conformation. Acta Crystallogr D Struct Biol, 72, 2016
7TMY	Structure of Mouse Importin alpha NEIL3 NLS Peptide Complex Descriptor: Importin subunit alpha-1, Nuclear Localization Signal from Endonuclease 8-like 3 Authors: Moraes, I.R, de Oliveira, H.C, Fontes, M.R.M. Deposit date: 2022-01-20 Release date: 2023-08-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha. Biochim Biophys Acta Proteins Proteom, 1872, 2023
7TMX	Structure of Mouse Importin alpha NEIL1 NLS Peptide Complex Descriptor: Importin subunit alpha-1, Nuclear Localization Signal from Endonuclease 8-like 1 Authors: Moraes, I.R, de Oliveira, H.C, Fontes, M.R.M. Deposit date: 2022-01-20 Release date: 2023-08-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha. Biochim Biophys Acta Proteins Proteom, 1872, 2023
1Y2A	Structure of mammalian importin bound to the non-classical PLSCR1-NLS Descriptor: Importin alpha-2 Subunit, decamer fragment of Phospholipid scramblase 1 Authors: Chen, M.-H, Ben-Efraim, I, Mitrousis, G, Walker-Kopp, N, Sims, P.J, Cingolani, G. Deposit date: 2004-11-22 Release date: 2005-02-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Phospholipid Scramblase 1 Contains a Nonclassical Nuclear Localization Signal with Unique Binding Site in Importin alpha J.Biol.Chem., 280, 2005

<12345678910111213141516>