4U58

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Summary for 4U58

DescriptorImportin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide (3 entities in total)
Functional Keywordstpx2 inhibitor, transport protein
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm  P52293
Total number of polymer chains1
Total molecular weight46470.22
Authors
Stewart, M.,Valkov, E.,Holvey, R.S. (deposition date: 2014-07-24, release date: 2015-05-13, Last modification date: 2015-07-08)
Primary citation
Holvey, R.S.,Valkov, E.,Neal, D.,Stewart, M.,Abell, C.
Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10:1232-1239, 2015
PubMed: 25899172 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201500014
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.56 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.265601.1%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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