4U5S
IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR
Summary for 4U5S
| Entry DOI | 10.2210/pdb4u5s/pdb |
| Descriptor | Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide (3 entities in total) |
| Functional Keywords | tpx2. inhibitor, minor site, transport protein |
| Biological source | Mus musculus (Mouse) |
| Cellular location | Cytoplasm : P52293 |
| Total number of polymer chains | 1 |
| Total formula weight | 47343.27 |
| Authors | Stewart, M.,Valkov, E.,Holvey, R.S. (deposition date: 2014-07-25, release date: 2015-05-13, Last modification date: 2017-06-21) |
| Primary citation | Holvey, R.S.,Valkov, E.,Neal, D.,Stewart, M.,Abell, C. Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10:1232-1239, 2015 Cited by PubMed: 25899172DOI: 10.1002/cmdc.201500014 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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