Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit

Summary for 3LWW

DescriptorImportin subunit beta-1, Snurportin-1 (2 entities in total)
Functional Keywordsprotein transport, heat repeat, ibb-domain, importin beta, karyopherin, snurportin
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q14974
Nucleus O95149
Total number of polymer chains4
Total molecular weight204571.13
Bhardwaj, A.,Cingolani, G. (deposition date: 2010-02-24, release date: 2010-06-02, Last modification date: 2011-07-13)
Primary citation
Bhardwaj, A.,Cingolani, G.
Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta.
Biochemistry, 49:5042-5047, 2010
PubMed: 20476751 (PDB entries with the same primary citation)
DOI: 10.1021/bi100292y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30532 0.6% 9.3% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02