Crystal structure of importin-alpha bound to a CLIC4 NLS peptide

Summary for 3OQS

Descriptorpeptide of Chloride intracellular channel protein 4, Importin subunit alpha-2 (3 entities in total)
Functional Keywordsimportin alpha, karyopherin alpha, nuclear localisation signal (nls) recognition, chloride intracellular channel 4, clic4 nls, armadillo repeat, nuclear import, protein transport
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm, cytoskeleton, centrosome Q9Y696
Cytoplasm (By similarity) P52293
Total number of polymer chains2
Total molecular weight56539.06
Mynott, A.V.,Brown, L.J.,Harrop, S.J.,Curmi, P.M.G. (deposition date: 2010-09-03, release date: 2011-07-27)
Primary citation
Mynott, A.V.,Harrop, S.J.,Brown, L.J.,Breit, S.N.,Kobe, B.,Curmi, P.M.G.
Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4
Febs J., 278:1662-1675, 2011
PubMed: 21388519 (PDB entries with the same primary citation)
DOI: 10.1111/j.1742-4658.2011.08086.x
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21790.2%1.4%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3oqs
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Molmil generated image of 3oqs
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Molmil generated image of 3oqs
rotated about y axis by 90°