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4A63
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BU of 4a63 by Molmil
Crystal structure of the p73-ASPP2 complex at 2.6A resolution
Descriptor: ACETATE ION, APOPTOSIS STIMULATING OF P53 PROTEIN 2, TUMOUR PROTEIN 73, ...
Authors:Canning, P, Sharpe, T, Krojer, T, Savitsky, P, Cooper, C.D.O, Salah, E, Keates, T, Muniz, J, Vollmar, M, von Delft, F, Weigelt, J, Arrowsmith, C, Bountra, C, Edwards, A, Bullock, A.N.
Deposit date:2011-10-31
Release date:2011-12-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73.
J.Mol.Biol., 423, 2012
3UAT
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BU of 3uat by Molmil
Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules
Descriptor: Disks large homolog 1, phosphor-LGN peptide
Authors:Shang, Y, Zhu, J, Wen, W, Zhang, M.
Deposit date:2011-10-22
Release date:2011-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
Embo J., 2011
3REA
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BU of 3rea by Molmil
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK
Authors:Schulte, A, Blankenfeldt, W, Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PLoS ONE, 6, 2011
3TVT
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BU of 3tvt by Molmil
Structural basis for Discs Large interaction with Pins
Descriptor: Disks large 1 tumor suppressor protein, Partner of Inscuteable
Authors:Johnston, C.A, Doe, C.Q, Prehoda, K.E.
Deposit date:2011-09-20
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for Discs Large interaction with Pins
To be Published
4ORZ
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BU of 4orz by Molmil
HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19
Authors:Geyer, M, Lulf, S.
Deposit date:2014-02-12
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11, 2014
4N78
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BU of 4n78 by Molmil
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
Descriptor: Abl interactor 2, CHLORIDE ION, Cytoplasmic FMR1-interacting protein 1, ...
Authors:Chen, Z.C.
Deposit date:2013-10-15
Release date:2014-02-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
Cell(Cambridge,Mass.), 156, 2014
3EHQ
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BU of 3ehq by Molmil
Crystal Structure of Human Osteoclast Stimulating Factor
Descriptor: 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1
Authors:Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
3EHR
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BU of 3ehr by Molmil
Crystal Structure of Human Osteoclast Stimulating Factor
Descriptor: Osteoclast-stimulating factor 1
Authors:Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L.
Deposit date:2008-09-14
Release date:2009-08-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human osteoclast stimulating factor
Proteins, 75, 2009
5FUL
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BU of 5ful by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with SAH
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
Deposit date:2016-01-27
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
FEBS J., 284, 2017
5FWD
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BU of 5fwd by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP2
Descriptor: 1,2-ETHANEDIOL, 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine, CALCIUM ION, ...
Authors:Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
Deposit date:2016-02-12
Release date:2017-03-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies of Protein Arginine Methyltransferase 2 Reveal its Interactions with Potential Substrates and Inhibitors.
FEBS J., 284, 2017
5FWA
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BU of 5fwa by Molmil
Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP1
Descriptor: 1,2-ETHANEDIOL, 9-(6-carbamimidamido-5,6-dideoxy-beta-D-ribo-hexofuranosyl)-9H-purin-6-amine, CALCIUM ION, ...
Authors:Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J.
Deposit date:2016-02-16
Release date:2016-11-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
FEBS J., 284, 2017
2LZ6
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BU of 2lz6 by Molmil
Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications
Descriptor: CD2-associated protein, Ubiquitin
Authors:Ortega-Roldan, J, Azuaga, A, Blackledge, M, Van Nuland, N.
Deposit date:2012-09-24
Release date:2013-10-02
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications.
Plos One, 8, 2013
2PZ1
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BU of 2pz1 by Molmil
Crystal Structure of Auto-inhibited Asef
Descriptor: Rho guanine nucleotide exchange factor 4
Authors:Betts, L, Sondek, J, Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
2MOX
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BU of 2mox by Molmil
solution structure of tandem SH3 domain of Sorbin and SH3 domain-containing protein 1
Descriptor: Sorbin and SH3 domain-containing protein 1
Authors:Zhao, D, Wang, C, Zhang, J, Wu, J, Shi, Y, Zhang, Z, Gong, Q.
Deposit date:2014-05-07
Release date:2014-05-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin
J.Struct.Biol., 187, 2014
1AVZ
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BU of 1avz by Molmil
V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN
Descriptor: FYN TYROSINE KINASE, NEGATIVE FACTOR
Authors:Arold, S, Franken, P, Dumas, C.
Deposit date:1997-09-23
Release date:1998-03-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure, 5, 1997
2ROL
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BU of 2rol by Molmil
Structural Basis of PxxDY motif recognition in SH3 binding
Descriptor: 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain, Epidermal growth factor receptor kinase substrate 8-like protein 1
Authors:Aitio, O, Hellman, M, Kesti, T, Kleino, I, Samuilova, O, Tossavainen, H, Paakkonen, K, Saksela, K, Permi, P.
Deposit date:2008-04-02
Release date:2009-03-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis of PxxDY motif recognition in SH3 binding
J.Mol.Biol., 382, 2008
5NUH
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BU of 5nuh by Molmil
Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
Authors:Horenkamp, F.A, Anand, K, Geyer, M.
Deposit date:2017-04-30
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3.
Nat Commun, 8, 2017
2XKX
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BU of 2xkx by Molmil
Single particle analysis of PSD-95 in negative stain
Descriptor: DISKS LARGE HOMOLOG 4
Authors:Fomina, S, Howard, T.D, Sleator, O.K, Golovanova, M, O'Ryan, L, Leyland, M.L, Grossmann, J.G, Collins, R.F, Prince, S.M.
Deposit date:2010-07-15
Release date:2011-07-20
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (22.9 Å), SOLUTION SCATTERING
Cite:Self-Directed Assembly and Clustering of the Cytoplasmic Domains of Inwardly Rectifying Kir2.1 Potassium Channels on Association with Psd-95
Biochim.Biophys.Acta, 1808, 2011
1NG2
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BU of 1ng2 by Molmil
Structure of autoinhibited p47phox
Descriptor: Neutrophil cytosolic factor 1
Authors:Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K.
Deposit date:2002-12-16
Release date:2003-05-20
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of phosphorylation-induced activation of the NADPH oxidase
Cell(Cambridge,Mass.), 113, 2003
1EFN
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BU of 1efn by Molmil
HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN
Descriptor: FYN TYROSINE KINASE, HIV-1 NEF PROTEIN, TRIMETHYL LEAD ION
Authors:Lee, C.-H, Kuriyan, J.
Deposit date:1996-06-29
Release date:1997-01-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Cell(Cambridge,Mass.), 85, 1996
1K4U
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BU of 1k4u by Molmil
Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox
Descriptor: PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX, PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX
Authors:Kami, K, Takeya, R, Sumimoto, H, Kohda, D.
Deposit date:2001-10-08
Release date:2002-04-08
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.
EMBO J., 21, 2002
1KJW
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BU of 1kjw by Molmil
SH3-Guanylate Kinase Module from PSD-95
Descriptor: POSTSYNAPTIC DENSITY PROTEIN 95, SULFATE ION
Authors:McGee, A.W, Dakoji, S.R, Olsen, O, Bredt, D.S, Lim, W.A, Prehoda, K.E.
Deposit date:2001-12-05
Release date:2002-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins
Mol.Cell, 8, 2001
1JXM
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BU of 1jxm by Molmil
CRYSTAL STRUCTURE OF THE GMP BOUND SH3-HOOK-GK FRAGMENT OF PSD-95
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GUANIDINE, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Tavares, G.A, Panepucci, E.H, Brunger, A.T.
Deposit date:2001-09-07
Release date:2002-01-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.
Mol.Cell, 8, 2001
1JXO
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BU of 1jxo by Molmil
Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95
Descriptor: postsynaptic density protein
Authors:Tavares, G.A, Panepucci, E.H, Brunger, A.T.
Deposit date:2001-09-07
Release date:2002-01-16
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.
Mol.Cell, 8, 2001
1U5S
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BU of 1u5s by Molmil
NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain
Descriptor: Cytoplasmic protein NCK2, PINCH protein, ZINC ION
Authors:Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J.
Deposit date:2004-07-28
Release date:2005-04-05
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility.
Mol.Cell, 17, 2005

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