3REA

HIV-1 Nef protein in complex with engineered Hck-SH3 domain

Summary for 3REA

Entry DOI	10.2210/pdb3rea/pdb
Related	1AVZ 1EFN 1QA5 2NEF 3RBB 3REB
Descriptor	Protein Nef, Tyrosine-protein kinase HCK (3 entities in total)
Functional Keywords	hiv-1 nef, sh3 domain binding, signaling, hck sh3 domain, protein binding
Biological source	HIV-1 M:B_ARV2/SF2 (HIV-1) More
Total number of polymer chains	4
Total formula weight	52382.63
Authors	Schulte, A.,Blankenfeldt, W.,Geyer, M. (deposition date: 2011-04-04, release date: 2011-06-01, Last modification date: 2023-09-13)
Primary citation	Breuer, S.,Schievink, S.I.,Schulte, A.,Blankenfeldt, W.,Fackler, O.T.,Geyer, M. Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6:e20033-e20033, 2011 Cited by PubMed: 21625496 DOI: 10.1371/journal.pone.0020033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation