1EFN

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

Summary for 1EFN

Entry DOI	10.2210/pdb1efn/pdb
Descriptor	FYN TYROSINE KINASE, HIV-1 NEF PROTEIN, TRIMETHYL LEAD ION, ... (4 entities in total)
Functional Keywords	complex (sh3 domain-viral enhancer), proto-oncogene, transferase, tyrosine-protein kinase, phosphorylation, aids, myristylation, gtp-binding, atp-binding, sh3 domain, sh2 domain, ppii helix, pxxp motif, complex (sh3 domain-viral enhancer) complex, complex (sh3 domain/viral enhancer)
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane: P06241 Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03406
Total number of polymer chains	4
Total formula weight	49427.04
Authors	Lee, C.-H.,Kuriyan, J. (deposition date: 1996-06-29, release date: 1997-01-11, Last modification date: 2024-02-07)
Primary citation	Lee, C.H.,Saksela, K.,Mirza, U.A.,Chait, B.T.,Kuriyan, J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell(Cambridge,Mass.), 85:931-942, 1996 Cited by PubMed: 8681387 DOI: 10.1016/S0092-8674(00)81276-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation