1EFN

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	FYN TYROSINE KINASE	polymer	59	6652.2	2	UniProt (P06241) Pfam (PF00018)	Homo sapiens (human)	SRC-HOMOLOGY 3 DOMAIN
2	B, D (B, D)	HIV-1 NEF PROTEIN	polymer	152	17809.0	2	UniProt (P03406) Pfam (PF00469)	Human immunodeficiency virus 1
3	E, F (B, D)	TRIMETHYL LEAD ION	non-polymer		252.3	2	Chemie (PBM)
4	G, H, I, J (A, B, C, D)	water	water		18.0	99	Chemie (HOH)

Sequence modifications

A, C: 86 - 143 (UniProt: P06241)

PDB	External Database	Details
Ile 96	Arg 95	engineered mutation

B, D: 54 - 205 (UniProt: P03406)

PDB	External Database	Details
Arg 71	Thr 71	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	48922.4
Non-Polymers*	Number of molecules	2
	Total formula weight	504.6
All*	Total formula weight	49427.0

*Water molecules are not included.