7BED
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7BCY
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![BU of 7bcy by Molmil](/molmil-images/mine/7bcy) | |
2KTU
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2KDP
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![BU of 2kdp by Molmil](/molmil-images/mine/2kdp) | Solution Structure of the SAP30 zinc finger motif | Descriptor: | Histone deacetylase complex subunit SAP30, ZINC ION | Authors: | He, Y, Imhoff, R, Sahu, A, Radhakrishnan, I. | Deposit date: | 2009-01-14 | Release date: | 2009-03-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition Nucleic Acids Res., 37, 2009
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4PJW
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![BU of 4pjw by Molmil](/molmil-images/mine/4pjw) | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1), with bound MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | Authors: | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | Deposit date: | 2014-05-12 | Release date: | 2014-08-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat.Struct.Mol.Biol., 21, 2014
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4PL7
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4PJT
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![BU of 4pjt by Molmil](/molmil-images/mine/4pjt) | Structure of PARP1 catalytic domain bound to inhibitor BMN 673 | Descriptor: | (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | Authors: | Aoyagi-Scharber, M, Gardberg, A.S, Arakaki, T.L. | Deposit date: | 2014-05-12 | Release date: | 2014-09-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone. Acta Crystallogr.,Sect.F, 70, 2014
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4PJU
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![BU of 4pju by Molmil](/molmil-images/mine/4pju) | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) | Descriptor: | Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | Authors: | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | Deposit date: | 2014-05-12 | Release date: | 2014-08-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat.Struct.Mol.Biol., 21, 2014
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4PL8
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4PK7
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![BU of 4pk7 by Molmil](/molmil-images/mine/4pk7) | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | Authors: | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | Deposit date: | 2014-05-13 | Release date: | 2014-09-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat.Struct.Mol.Biol., 21, 2014
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7EPZ
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![BU of 7epz by Molmil](/molmil-images/mine/7epz) | Overall structure of Erastin-bound xCT-4F2hc complex | Descriptor: | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R.H, Li, Y.N, Zhang, Y.Y, Chi, X.M, Zhou, Q. | Deposit date: | 2021-04-28 | Release date: | 2022-04-06 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis. Cell Res., 32, 2022
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4RXQ
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![BU of 4rxq by Molmil](/molmil-images/mine/4rxq) | The structure of GTP-dUTP-bound SAMHD1 | Descriptor: | DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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4RXO
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![BU of 4rxo by Molmil](/molmil-images/mine/4rxo) | The structure of GTP-bound SAMHD1 | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... | Authors: | Zhu, C.F, Wei, W, Peng, X, Dong, Y.H, Gong, Y, Yu, X.F. | Deposit date: | 2014-12-11 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. Acta Crystallogr.,Sect.D, 71, 2015
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7EQ7
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![BU of 7eq7 by Molmil](/molmil-images/mine/7eq7) | |
4RV6
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2KIZ
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![BU of 2kiz by Molmil](/molmil-images/mine/2kiz) | Solution structure of Arkadia RING-H2 finger domain | Descriptor: | E3 ubiquitin-protein ligase Arkadia, ZINC ION | Authors: | Kandias, N.G, Chasapis, C.T, Bentrop, D, Episkopou, V, Spyroulias, G.A. | Deposit date: | 2009-05-13 | Release date: | 2010-05-19 | Last modified: | 2013-03-20 | Method: | SOLUTION NMR | Cite: | NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase. Proteins, 80, 2012
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4TO0
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![BU of 4to0 by Molmil](/molmil-images/mine/4to0) | Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dCTP complex | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | Authors: | Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. | Deposit date: | 2014-06-05 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
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4TO3
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![BU of 4to3 by Molmil](/molmil-images/mine/4to3) | Structural basis of cellular dNTP regulation, SAMHD1-dGTP-dGTP-dCTP complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | Authors: | Ji, X, Tang, C, Zhao, Q, Wang, W, Xiong, Y. | Deposit date: | 2014-06-05 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of cellular dNTP regulation by SAMHD1. Proc.Natl.Acad.Sci.USA, 111, 2014
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2KMD
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![BU of 2kmd by Molmil](/molmil-images/mine/2kmd) | Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to co-activator CBP | Descriptor: | Protein C-ets-1 | Authors: | Nelson, M.L, Kang, H, Lee, G.M, Blaszczak, A.G, Lau, D.K.W, McIntosh, L.P, Graves, B.J. | Deposit date: | 2009-07-27 | Release date: | 2010-05-05 | Last modified: | 2012-03-21 | Method: | SOLUTION NMR | Cite: | Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc.Natl.Acad.Sci.USA, 107, 2010
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2KTV
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7C2Z
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![BU of 7c2z by Molmil](/molmil-images/mine/7c2z) | Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4, FORMIC ACID | Authors: | Li, J, Zhu, J. | Deposit date: | 2020-05-10 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
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2KTB
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2KNV
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4O78
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![BU of 4o78 by Molmil](/molmil-images/mine/4o78) | Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, CHLORIDE ION, ... | Authors: | Zhu, J.-Y, Ember, S.W, Watts, C, Schonbrunn, E. | Deposit date: | 2013-12-24 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
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2KRM
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![BU of 2krm by Molmil](/molmil-images/mine/2krm) | |