4PK7

crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins

Summary for 4PK7

• Entry DOI: 10.2210/pdb4pk7/pdb
• Descriptor: Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: sister chromatid cohesion, cohesin subunits, protein-protein interaction, heat repeat, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 131948.27

Authors

Hara, K.,Chen, Z.,Tomchick, D.R.,Yu, H. (deposition date: 2014-05-13, release date: 2014-09-03, Last modification date: 2023-09-27)

• Primary citation: Hara, K.,Zheng, G.,Qu, Q.,Liu, H.,Ouyang, Z.,Chen, Z.,Tomchick, D.R.,Yu, H.; Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.; Nat.Struct.Mol.Biol., 21:864-870, 2014; PubMed: 25173175; DOI: 10.1038/nsmb.2880

Experimental method

X-RAY DIFFRACTION (2.95 Å)