7EPZ

Overall structure of Erastin-bound xCT-4F2hc complex

Summary for 7EPZ

• Entry DOI: 10.2210/pdb7epz/pdb
• EMDB information: 31251
• Descriptor: 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 131423.23

Authors

Yan, R.H.,Li, Y.N.,Zhang, Y.Y.,Chi, X.M.,Zhou, Q. (deposition date: 2021-04-28, release date: 2022-04-06, Last modification date: 2022-07-13)

• Primary citation: Yan, R.,Xie, E.,Li, Y.,Li, J.,Zhang, Y.,Chi, X.,Hu, X.,Xu, L.,Hou, T.,Stockwell, B.R.,Min, J.,Zhou, Q.,Wang, F.; The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis.; Cell Res., 32:687-690, 2022; PubMed: 35352032; DOI: 10.1038/s41422-022-00642-w

Experimental method

ELECTRON MICROSCOPY (3.4 Å)