7EPZ
Overall structure of Erastin-bound xCT-4F2hc complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006865 | biological_process | amino acid transport |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006865 | biological_process | amino acid transport |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0007420 | biological_process | brain development |
| B | 0008542 | biological_process | visual learning |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0009986 | cellular_component | cell surface |
| B | 0014070 | biological_process | response to organic cyclic compound |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015327 | molecular_function | cystine:glutamate antiporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015811 | biological_process | L-cystine transport |
| B | 0015813 | biological_process | L-glutamate transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0021591 | biological_process | ventricular system development |
| B | 0021756 | biological_process | striatum development |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030534 | biological_process | adult behavior |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0033029 | biological_process | regulation of neutrophil apoptotic process |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0034775 | biological_process | glutathione transmembrane transport |
| B | 0035094 | biological_process | response to nicotine |
| B | 0042127 | biological_process | regulation of cell population proliferation |
| B | 0042995 | cellular_component | cell projection |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0048021 | biological_process | regulation of melanin biosynthetic process |
| B | 0048286 | biological_process | lung alveolus development |
| B | 0050804 | biological_process | modulation of chemical synaptic transmission |
| B | 0050807 | biological_process | regulation of synapse organization |
| B | 0051223 | biological_process | regulation of protein transport |
| B | 0051775 | biological_process | response to redox state |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060173 | biological_process | limb development |
| B | 0070306 | biological_process | lens fiber cell differentiation |
| B | 0070527 | biological_process | platelet aggregation |
| B | 0071702 | biological_process | obsolete organic substance transport |
| B | 0090461 | biological_process | intracellular glutamate homeostasis |
| B | 0097449 | cellular_component | astrocyte projection |
| B | 0098712 | biological_process | L-glutamate import across plasma membrane |
| B | 0110076 | biological_process | negative regulation of ferroptosis |
| B | 0140206 | biological_process | dipeptide import across plasma membrane |
| B | 0140924 | biological_process | L-kynurenine transmembrane transport |
| B | 0140926 | molecular_function | L-kynurenine transmembrane transporter activity |
| B | 1900407 | biological_process | regulation of cellular response to oxidative stress |
| B | 1901494 | biological_process | regulation of cysteine metabolic process |
| B | 1902475 | biological_process | L-alpha-amino acid transmembrane transport |
| B | 1903786 | biological_process | regulation of glutathione biosynthetic process |
| B | 1904717 | biological_process | regulation of AMPA glutamate receptor clustering |
| B | 2000211 | biological_process | regulation of glutamate metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:15151999 |
| Chain | Residue | Details |
| B | VAL44-ILE64 | |
| B | LEU388-ILE408 | |
| B | VAL423-LEU443 | |
| B | THR450-TRP470 | |
| B | SER75-LEU95 | |
| B | LEU131-ILE150 | |
| B | ALA164-LEU179 | |
| B | LEU194-VAL210 | |
| B | LEU235-VAL255 | |
| B | ILE266-VAL286 | |
| B | ALA318-VAL338 | |
| B | PRO365-LEU385 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:15151999 |
| Chain | Residue | Details |
| B | SER65-GLY74 | |
| B | LEU151-LEU163 | |
| B | MET211-ARG234 | |
| B | ALA287-LEU317 | |
| B | ASP386-SER387 | |
| B | TYR444-SER449 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:15151999 |
| Chain | Residue | Details |
| B | SER96-GLY101 | |
| B | VAL117-GLU130 | |
| B | ASN180-PHE193 | |
| B | THR256-THR265 | |
| B | SER339-THR364 | |
| B | TYR409-LYS422 | |
| B | ASP471-LEU501 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | INTRAMEM: INTRAMEM => ECO:0000305|PubMed:15151999 |
| Chain | Residue | Details |
| B | THR102-GLU116 | |
| A | MET134 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34880232, ECO:0007744|PDB:7P9U |
| Chain | Residue | Details |
| B | ARG135 | |
| B | TYR244 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER26 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN314 | |
| A | ASP408 | |
| A | GLY410 | |
| A | LEU527 | |
| A | ARG531 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | GLN365 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | THR381 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | LEU424 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ALA506 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | ILE147 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | SER166 |
