4RV6

Human ARTD1 (PARP1) catalytic domain in complex with inhibitor Rucaparib

Summary for 4RV6

Entry DOI	10.2210/pdb4rv6/pdb
Related	4r5w 4r6e 4und 4uxb
Descriptor	Poly [ADP-ribose] polymerase 1, SULFATE ION, Rucaparib, ... (4 entities in total)
Functional Keywords	adp-ribosyl transferase, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	158771.42
Authors	Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2014-11-25, release date: 2015-12-09, Last modification date: 2023-09-20)
Primary citation	Thorsell, A.G.,Ekblad, T.,Karlberg, T.,Low, M.,Pinto, A.F.,Tresaugues, L.,Moche, M.,Cohen, M.S.,Schuler, H. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60:1262-1271, 2017 Cited by PubMed: 28001384 DOI: 10.1021/acs.jmedchem.6b00990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.19 Å)

Structure validation