4RV6
Human ARTD1 (PARP1) catalytic domain in complex with inhibitor Rucaparib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Poly [ADP-ribose] polymerase 1 | polymer | 352 | 39387.1 | 4 | UniProt (P09874) Pfam (PF02877) Pfam (PF00644) | Homo sapiens (human) | PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1 |
| 2 | E, F, H, I, K... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | G, J (A, B) | Rucaparib | non-polymer | 323.4 | 2 | Chemie (RPB) | |||
| 4 | M, N, O (B, C, D) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 662 - 1011 (UniProt: P09874)
| PDB | External Database | Details |
|---|---|---|
| Ser 660 | - | expression tag |
| Met 661 | - | expression tag |
| Ala 762 | Val 762 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157548.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1223.1 | |
| All* | Total formula weight | 158771.4 |
