PDB: 439 resultsInfo pagesStatus searchChemie searchBIRD

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2JZQ	Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures Descriptor: Insulin Authors: Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A. Deposit date: 2008-01-11 Release date: 2008-02-26 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J.Biol.Chem., 283, 2008
2L1Y	NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures Descriptor: Insulin A chain, Insulin B chain Authors: Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. Deposit date: 2010-08-09 Release date: 2011-08-31 Method: SOLUTION NMR Cite: Chiral Protein Engineering and its Application in G Health To be Published
2M2N	Structure of [L-HisB24] insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2M2O	Structure of [D-HisB24] insulin analogue at pH 1.9 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2013-06-05 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2MLI	NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin Descriptor: Insulin Authors: Yang, Y, Weiss, M. Deposit date: 2014-02-27 Release date: 2014-08-20 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2KJJ	Dynamics of insulin probed by 1H-NMR amide proton exchange anomalous flexibility of the receptor-binding surface Descriptor: Insulin Authors: Hua, Q.X, Weiss, M.A. Deposit date: 2009-05-29 Release date: 2010-06-16 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Dynamics of Insulin Probed by 1H-NMR Amide Proton E Anomalous Flexibility of the Receptor-Binding Surfa To be Published
2K9R	Enhancing the activity of insulin by stereospecific unfolding Descriptor: Insulin Authors: Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2008-10-23 Release date: 2008-11-11 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
2KQP	NMR Structure of Proinsulin Descriptor: Insulin Authors: Yang, Y, Hua, Q.X, Mackin, R.B, Weiss, M.A. Deposit date: 2009-11-12 Release date: 2010-01-26 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Solution structure of proinsulin: connecting domain flexibility and prohormone processing. J.Biol.Chem., 285, 2010
2LWZ	NMR Structures of Single-chain Insulin Descriptor: SINGLE-CHAIN INSULIN Authors: Weiss, M.A, Yang, Y. Deposit date: 2012-08-09 Release date: 2013-08-28 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Dynamic repair of an amyloidogenic protein: Insulin fibrillation is blocked by tethering a nascent alpha-helix To be Published
2M1D	Biosynthetic engineered B28K-B29P human insulin monomer structure in in water/acetonitrile solutions. Descriptor: Insulin Authors: Bocian, W, Kozerski, L. Deposit date: 2012-11-26 Release date: 2013-02-27 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. J.Biomol.Nmr, 55, 2013
2M2P	Structure of [D-HisB24] insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Zakova, L, Veverka, V, Jiracek, J. Deposit date: 2012-12-29 Release date: 2013-03-06 Last modified: 2024-11-06 Method: SOLUTION NMR Cite: Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
4CXN	Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. Deposit date: 2014-04-07 Release date: 2014-05-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
4E7V	The structure of R6 bovine insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Harris, P, Frankaer, C.G, Knudsen, M.V. Deposit date: 2012-03-19 Release date: 2012-04-04 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The structures of T(6), T(3)R(3) and R(6) bovine insulin: combining X-ray diffraction and absorption spectroscopy. Acta Crystallogr.,Sect.D, 68, 2012
4EWX	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-28 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EXX	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-01 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EY1	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-01 Release date: 2013-05-01 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.471 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4BS3	Bovin insulin structure determined by in situ crystal analysis and sulfur-SAD phasing at room temperature Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Pinker, F, Stirnimann, C, Sauter, C, Olieric, V. Deposit date: 2013-06-06 Release date: 2013-07-17 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Chipx: A Novel Microfluidic Chip for Counter- Diffusion Crystallization of Biomolecules and in Situ Crystal Analysis at Room Temperature J.Cryst.Growth, 13, 2013
4CY7	Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... Authors: Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. Deposit date: 2014-04-10 Release date: 2014-05-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
4EWZ	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-29 Release date: 2013-05-01 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.791 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4E7U	The structure of T3R3 bovine insulin Descriptor: Insulin A chain, Insulin B chain, THIOCYANATE ION, ... Authors: Harris, P, Frankaer, C.G, Knudsen, M.V. Deposit date: 2012-03-19 Release date: 2012-04-04 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The structures of T(6), T(3)R(3) and R(6) bovine insulin: combining X-ray diffraction and absorption spectroscopy. Acta Crystallogr.,Sect.D, 68, 2012
4EWW	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-28 Release date: 2013-05-01 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EX0	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-04-29 Release date: 2013-05-01 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EYN	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-01 Release date: 2013-05-01 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.532 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4F0O	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-04 Release date: 2013-05-08 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.672 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4F0N	Human Insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. Deposit date: 2012-05-04 Release date: 2013-05-08 Last modified: 2013-12-18 Method: X-RAY DIFFRACTION (1.679 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013

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