7E5A
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![BU of 7e5a by Molmil](/molmil-images/mine/7e5a) | interferon-inducible anti-viral protein R356A | Descriptor: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, Guanylate-binding protein 5, ... | Authors: | Cui, W, Wang, W, Chen, C, Slater, B, Xiong, Y, Ji, X.Y, Yang, H.T. | Deposit date: | 2021-02-18 | Release date: | 2021-05-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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6G19
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![BU of 6g19 by Molmil](/molmil-images/mine/6g19) | CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-20 | Release date: | 2018-11-21 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G1X
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![BU of 6g1x by Molmil](/molmil-images/mine/6g1x) | CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-22 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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6G1S
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![BU of 6g1s by Molmil](/molmil-images/mine/6g1s) | CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist | Descriptor: | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3'), RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), ... | Authors: | Yu, Q, Qu, K, Modis, Y. | Deposit date: | 2018-03-21 | Release date: | 2018-11-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol. Cell, 72, 2018
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4N71
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![BU of 4n71 by Molmil](/molmil-images/mine/4n71) | X-Ray Crystal Structure of 2-amino-1-hydroxyethylphosphonate-bound PhnZ | Descriptor: | FE (III) ION, Predicted HD phosphohydrolase PhnZ, [(1R)-2-amino-1-hydroxyethyl]phosphonic acid | Authors: | Woersdoerfer, B, Lingaraju, M, Yennawar, N, Boal, A.K, Krebs, C, Bollinger Jr, J.M, Pandelia, M.-E. | Deposit date: | 2013-10-14 | Release date: | 2013-11-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.984 Å) | Cite: | Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases. Proc.Natl.Acad.Sci.USA, 110, 2013
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6DHI
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![BU of 6dhi by Molmil](/molmil-images/mine/6dhi) | |
1EKU
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![BU of 1eku by Molmil](/molmil-images/mine/1eku) | CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA | Descriptor: | Interferon gamma, SULFATE ION | Authors: | Landar, A, Curry, B, Parker, M.H, DiGiacomo, R, Indelicato, S.R, Walter, M.R. | Deposit date: | 2000-03-09 | Release date: | 2000-09-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J.Mol.Biol., 299, 2000
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3BU8
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![BU of 3bu8 by Molmil](/molmil-images/mine/3bu8) | Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex | Descriptor: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 | Authors: | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | Deposit date: | 2008-01-02 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
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4L5Q
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![BU of 4l5q by Molmil](/molmil-images/mine/4l5q) | Crystal structure of p202 HIN1 | Descriptor: | Interferon-activable protein 202 | Authors: | Yin, Q, Tian, Y, Wu, H. | Deposit date: | 2013-06-11 | Release date: | 2013-07-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep, 4, 2013
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4L5T
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![BU of 4l5t by Molmil](/molmil-images/mine/4l5t) | Crystal structure of the tetrameric p202 HIN2 | Descriptor: | Interferon-activable protein 202 | Authors: | Yin, Q, Tian, Y, Wu, H. | Deposit date: | 2013-06-11 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.405 Å) | Cite: | Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Rep, 4, 2013
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6C6K
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![BU of 6c6k by Molmil](/molmil-images/mine/6c6k) | Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced protein with tetratricopeptide repeats 3, MAGNESIUM ION, ... | Authors: | Amarasinghe, G.K, Leung, D.W, Johnson, B, Xu, W. | Deposit date: | 2018-01-18 | Release date: | 2018-04-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity, 48, 2018
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4WHJ
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![BU of 4whj by Molmil](/molmil-images/mine/4whj) | |
7K3R
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![BU of 7k3r by Molmil](/molmil-images/mine/7k3r) | Cryo-EM structure of AIM2-PYD filament | Descriptor: | Interferon-inducible protein AIM2 | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2020-09-12 | Release date: | 2021-05-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat Commun, 12, 2021
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8IZN
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![BU of 8izn by Molmil](/molmil-images/mine/8izn) | |
8H6Q
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![BU of 8h6q by Molmil](/molmil-images/mine/8h6q) | Class I sesquiterpene synthase BCBOT2 (apo) | Descriptor: | Presilphiperfolan-8-beta-ol synthase | Authors: | Lou, T.T, Ma, M. | Deposit date: | 2022-10-18 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis. J.Am.Chem.Soc., 2023
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5OEN
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![BU of 5oen by Molmil](/molmil-images/mine/5oen) | Crystal Structure of STAT2 in complex with IRF9 | Descriptor: | Interferon regulatory factor 9, Signal transducer and activator of transcription | Authors: | Rengachari, S, Panne, D. | Deposit date: | 2017-07-09 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.919 Å) | Cite: | Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7X45
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![BU of 7x45 by Molmil](/molmil-images/mine/7x45) | Grass carp interferon gamma related | Descriptor: | Interferon gamma | Authors: | Wang, J, Zou, J, Zhu, X. | Deposit date: | 2022-03-02 | Release date: | 2022-09-14 | Last modified: | 2023-04-19 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Novel Dimeric Architecture of an IFN-gamma-Related Cytokine Provides Insights into Subfunctionalization of Type II IFNs in Teleost Fish. J Immunol., 209, 2022
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1AHM
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![BU of 1ahm by Molmil](/molmil-images/mine/1ahm) | DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, 10 STRUCTURES | Descriptor: | DER F 2 | Authors: | Ichikawa, S, Hatanaka, H, Yuuki, T, Iwamoto, N, Ogura, K, Okumura, Y, Inagaki, F. | Deposit date: | 1997-04-07 | Release date: | 1998-04-08 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of Der f 2, the major mite allergen for atopic diseases. J.Biol.Chem., 273, 1998
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1AHK
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![BU of 1ahk by Molmil](/molmil-images/mine/1ahk) | DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | DER F 2 | Authors: | Ichikawa, S, Hatanaka, H, Yuuki, T, Iwamoto, N, Ogura, K, Okumura, Y, Inagaki, F. | Deposit date: | 1997-04-07 | Release date: | 1998-04-08 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of Der f 2, the major mite allergen for atopic diseases. J.Biol.Chem., 273, 1998
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7WKH
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![BU of 7wkh by Molmil](/molmil-images/mine/7wkh) | the grass carp IFNa | Descriptor: | Interferon | Authors: | Zou, J, WANG, J, Wang, Z. | Deposit date: | 2022-01-09 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural and Functional Analyses of Type I IFNa Shed Light Into Its Interaction With Multiple Receptors in Fish. Front Immunol, 13, 2022
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7DNJ
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![BU of 7dnj by Molmil](/molmil-images/mine/7dnj) | K63-polyUb MDA5CARDs complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7DNI
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![BU of 7dni by Molmil](/molmil-images/mine/7dni) | MDA5 CARDs-MAVS CARD polyUb complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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8JKS
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![BU of 8jks by Molmil](/molmil-images/mine/8jks) | |
8JKL
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![BU of 8jkl by Molmil](/molmil-images/mine/8jkl) | IRF4 DNA-binding domain bound to an DNA containing GATA motif | Descriptor: | GATA-Forward, GATA-Reverse, Interferon regulatory factor 4 | Authors: | Wang, G, Feng, X, Ding, J. | Deposit date: | 2023-06-01 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency. Structure, 31, 2023
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8JKQ
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![BU of 8jkq by Molmil](/molmil-images/mine/8jkq) | |