7K3R

Cryo-EM structure of AIM2-PYD filament

Summary for 7K3R

• Entry DOI: 10.2210/pdb7k3r/pdb
• EMDB information: 22656
• Descriptor: Interferon-inducible protein AIM2 (1 entity in total)
• Functional Keywords: inflammasome, aim2 filament, helical reconstruction, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 21
• Total formula weight: 284101.76

Authors

Zheng, W.,Matyszewski, M.,Sohn, J.,Egelman, E.H. (deposition date: 2020-09-12, release date: 2021-05-26, Last modification date: 2024-03-06)

• Primary citation: Matyszewski, M.,Zheng, W.,Lueck, J.,Mazanek, Z.,Mohideen, N.,Lau, A.Y.,Egelman, E.H.,Sohn, J.; Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.; Nat Commun, 12:2735-2735, 2021; PubMed: 33980849; DOI: 10.1038/s41467-021-23045-8

Experimental method

ELECTRON MICROSCOPY (3.2 Å)