PDB: 43 件ウェブページステータス検索Chemie searchBIRD

---

5OAQ	TEAD4 COMPLEXED WITH YAP PEPTIDE AND MYRISTATE (COVALENTLY BOUND) 分子名称: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2017-06-23 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ. Protein Sci., 26, 2017
5NO6	TEAD4-HOXB13 complex bound to DNA 分子名称: DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 著者 Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. 登録日 2017-04-11 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 TEAD4-HOXB13 complex bound to DNA To Be Published
3JUA	Structural basis of YAP recognition by TEAD4 in the Hippo pathway 分子名称: 65 kDa Yes-associated protein, Transcriptional enhancer factor TEF-3 著者 Chen, L, Song, H. 登録日 2009-09-15 公開日 2010-02-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of YAP recognition by TEAD4 in the hippo pathway. Genes Dev., 24, 2010
5GZB	Crystal Structure of Transcription Factor TEAD4 in Complex with M-CAT DNA 分子名称: DNA (5'-D(*GP*AP*GP*AP*GP*GP*AP*AP*TP*GP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*CP*AP*TP*TP*CP*CP*TP*CP*TP*C)-3'), GLYCEROL, ... 著者 He, F, Shi, Z.B, Zhou, Z.C. 登録日 2016-09-28 公開日 2017-04-19 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.704 Å) 主引用文献 DNA-binding mechanism of the Hippo pathway transcription factor TEAD4 Oncogene, 36, 2017
6L9F	Crystal structure of TEAD4 in complex with a novel FAM181A peptide 分子名称: ACETATE ION, Protein FAM181A, Transcriptional enhancer factor TEF-3 著者 Chen, M, Zhou, Z. 登録日 2019-11-09 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.555 Å) 主引用文献 Crystal structure of TEAD4 in complex with a novel FAM181A peptide To be published
5Z2Q	Vgll1-TEAD4 core complex 分子名称: PHOSPHATE ION, Transcription cofactor vestigial-like protein 1, Transcriptional enhancer factor TEF-3 著者 Pobbati, A.V, Song, H. 登録日 2018-01-03 公開日 2018-01-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure, 20, 2012
8A8R	Crystal structure of TEAD4 in complex with YAP peptide 分子名称: Isoform 7 of Transcriptional coactivator YAP1, MYRISTIC ACID, Transcriptional enhancer factor TEF-3 著者 Scheufler, C, Kallen, J. 登録日 2022-06-23 公開日 2022-12-28 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.696 Å) 主引用文献 N-terminal beta-strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor. Protein Sci., 32, 2023
6Q2X	TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.1A (P41212 CRYSTAL FORM) 分子名称: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2018-12-03 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence. Bioorg.Med.Chem.Lett., 29, 2019
6Q36	TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A resolution: Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence 分子名称: ACE-PRO-6CW-ARG-LEU-ARG-LYS-2JH-HYP-ASP-SER-PHE-ALN-LYS-GLU-PRO-NH2, MYRISTIC ACID, PHOSPHATE ION, ... 著者 Kallen, J. 登録日 2018-12-03 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence. Bioorg.Med.Chem.Lett., 29, 2019
6SEO	TEAD4 bound to a FAM181B peptide 分子名称: Protein FAM181B, Transcriptional enhancer factor TEF-3 著者 Scheufler, C, Villard, F. 登録日 2019-07-30 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein Sci., 29, 2020
6SEN	TEAD4 bound to a FAM181A peptide 分子名称: Protein FAM181A, SULFATE ION, Transcriptional enhancer factor TEF-3 著者 Scheufler, C, Villard, F. 登録日 2019-07-30 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein Sci., 29, 2020
6GE4	TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 1.97A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-25 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GE5	TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.05A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-25 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GEC	TEAD4 (216-434) COMPLEXED WITH YAP PEPTIDE (60-100);S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.70A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-26 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GEI	TEAD4 (216-434);E263A+Y429F COMPLEXED WITH YAP PEPTIDE (60- 100);S94A AND MYRISTOATE (COVALENTLY BOUND TO LYS344, NOT CYS367!) AT 1.65A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2018-04-26 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GEG	TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 2.23A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-26 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GEK	TEAD4 (216-434);Y429F COMPLEXED WITH YAP PEPTIDE (60-100) AND MYRISTOATE (COVALENTLY BOUND) AT 2.28A (P212121 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-26 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GEE	TEAD4 (216-434);E263A COMPLEXED WITH YAP PEPTIDE (60-100); S94A AND MYRISTOATE (COVALENTLY BOUND) AT 1.96A (P41212 CRYSTAL FORM); MYRISTOYLATION WAS DONE BY ADDING MYR-COA 分子名称: MYRISTIC ACID, Transcriptional coactivator YAP1, Transcriptional enhancer factor TEF-3 著者 Kallen, J. 登録日 2018-04-26 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
4LN0	Crystal structure of the VGLL4-TEAD4 complex 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Transcription cofactor vestigial-like protein 4, ... 著者 Wang, H, Shi, Z, Zhou, Z. 登録日 2013-07-11 公開日 2014-02-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell, 25, 2014
6HIK	X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy 分子名称: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2018-08-30 公開日 2019-04-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy. Febs J., 286, 2019
5GN0	Structure of TAZ-TEAD complex 分子名称: CITRIC ACID, PALMITIC ACID, Transcriptional enhancer factor TEF-3, ... 著者 Kaan, H.Y.K, Song, H. 登録日 2016-07-18 公開日 2017-05-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex Sci Rep, 7, 2017
8C17	Crystal structure of TEAD4 in complex with peptide 1 分子名称: GLYCEROL, MYRISTIC ACID, Stapled peptide, ... 著者 Scheufler, C, Kallen, J. 登録日 2022-12-20 公開日 2023-03-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD. Acs Chem.Biol., 18, 2023
8CAA	Crystal structure of TEAD4 in complex with YTP-13 分子名称: (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, PHOSPHATE ION, ... 著者 Scheufler, C, Kallen, J. 登録日 2023-01-24 公開日 2023-04-12 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. Chemmedchem, 18, 2023
6GE6	X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface 分子名称: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2018-04-25 公開日 2018-09-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6GE3	X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface 分子名称: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ... 著者 Kallen, J. 登録日 2018-04-25 公開日 2018-09-19 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018

 

12>