6GE6

X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface

Summary for 6GE6

Entry DOI	10.2210/pdb6ge6/pdb
Related	6GE3 6GE4 6GE5
Descriptor	Transcriptional enhancer factor TEF-3, Transcriptional coactivator YAP1, MYRISTIC ACID, ... (5 entities in total)
Functional Keywords	transcription factor, co-activator, transcription regulation, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30685.25
Authors	Kallen, J. (deposition date: 2018-04-25, release date: 2018-09-19, Last modification date: 2024-01-17)
Primary citation	Mesrouze, Y.,Bokhovchuk, F.,Izaac, A.,Meyerhofer, M.,Zimmermann, C.,Fontana, P.,Schmelzle, T.,Erdmann, D.,Furet, P.,Kallen, J.,Chene, P. Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27:1810-1820, 2018 Cited by PubMed: 30058229 DOI: 10.1002/pro.3493 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation