6GE6
X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface
Summary for 6GE6
Entry DOI | 10.2210/pdb6ge6/pdb |
Related | 6GE3 6GE4 6GE5 |
Descriptor | Transcriptional enhancer factor TEF-3, Transcriptional coactivator YAP1, MYRISTIC ACID, ... (5 entities in total) |
Functional Keywords | transcription factor, co-activator, transcription regulation, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30685.25 |
Authors | Kallen, J. (deposition date: 2018-04-25, release date: 2018-09-19, Last modification date: 2024-01-17) |
Primary citation | Mesrouze, Y.,Bokhovchuk, F.,Izaac, A.,Meyerhofer, M.,Zimmermann, C.,Fontana, P.,Schmelzle, T.,Erdmann, D.,Furet, P.,Kallen, J.,Chene, P. Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27:1810-1820, 2018 Cited by PubMed: 30058229DOI: 10.1002/pro.3493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report