6GE6
X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transcriptional enhancer factor TEF-3 | polymer | 219 | 25426.7 | 1 | UniProt (Q15561) Pfam (PF17725) | Homo sapiens (Human) | TEA domain family member 4,TEAD-4,Transcription factor 13-like 1,Transcription factor RTEF-1 |
| 2 | B (L) | Transcriptional coactivator YAP1 | polymer | 41 | 4650.3 | 1 | UniProt (P46937) Pfam (PF15238) | Homo sapiens (Human) | Yes-associated protein 1,Protein yorkie homolog,Yes-associated protein YAP65 homolog |
| 3 | C (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 4 | D, E, F, G (A) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | H, I (A, L) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 216 - 434 (UniProt: Q15561)
| PDB | External Database | Details |
|---|---|---|
| Ala 263 | Glu 220 | engineered mutation |
| Phe 429 | Tyr 386 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30077.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 608.3 | |
| All* | Total formula weight | 30685.3 |
