6GE6
X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MYR A 501 |
| Chain | Residue |
| A | VAL334 |
| A | LYS344 |
| A | CYS367 |
| A | ILE395 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | SER253 |
| A | SER254 |
| A | HIS426 |
| A | HOH617 |
| A | HOH654 |
| A | HOH661 |
| A | HOH705 |
| A | GLY216 |
| A | HIS249 |
| A | ILE250 |
| A | GLY251 |
| A | GLN252 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | ARG351 |
| A | ARG351 |
| A | SER358 |
| A | ARG360 |
| A | HOH623 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 504 |
| Chain | Residue |
| A | GLU228 |
| A | LYS244 |
| A | SER317 |
| A | HIS362 |
| A | HIS362 |
| A | HOH627 |
| A | HOH628 |
| A | HOH642 |
| A | HOH655 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 505 |
| Chain | Residue |
| A | GLN319 |
| A | ARG360 |
| A | HIS362 |
| A | ARG363 |
| A | HOH628 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by LATS1 and LATS2","evidences":[{"source":"PubMed","id":"17974916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18158288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
