8C17

Crystal structure of TEAD4 in complex with peptide 1

Summary for 8C17

• Entry DOI: 10.2210/pdb8c17/pdb
• Descriptor: Transcriptional enhancer factor TEF-3, Stapled peptide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: complex, inhibitor, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28260.91

Authors

Scheufler, C.,Kallen, J. (deposition date: 2022-12-20, release date: 2023-03-15, Last modification date: 2023-03-29)

• Primary citation: Mesrouze, Y.,Gubler, H.,Villard, F.,Boesch, R.,Ottl, J.,Kallen, J.,Reid, P.C.,Scheufler, C.,Marzinzik, A.L.,Chene, P.; Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD.; Acs Chem.Biol., 18:643-651, 2023; PubMed: 36825662; DOI: 10.1021/acschembio.2c00936

Experimental method

X-RAY DIFFRACTION (2.25 Å)