8CAA

Crystal structure of TEAD4 in complex with YTP-13

Summary for 8CAA

Entry DOI	10.2210/pdb8caa/pdb
Descriptor	Transcriptional enhancer factor TEF-3, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, ... (5 entities in total)
Functional Keywords	complex, inhibitor, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	53271.06
Authors	Scheufler, C.,Kallen, J. (deposition date: 2023-01-24, release date: 2023-04-12, Last modification date: 2023-06-14)
Primary citation	Sellner, H.,Chapeau, E.,Furet, P.,Voegtle, M.,Salem, B.,Le Douget, M.,Bordas, V.,Groell, J.M.,Le Goff, A.L.,Rouzet, C.,Wietlisbach, T.,Zimmermann, T.,McKenna, J.,Brocklehurst, C.E.,Chene, P.,Wartmann, M.,Scheufler, C.,Kallen, J.,Williams, G.,Harlfinger, S.,Traebert, M.,Dumotier, B.M.,Schmelzle, T.,Soldermann, N. Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. Chemmedchem, 18:e202300051-e202300051, 2023 Cited by PubMed: 36988034 DOI: 10.1002/cmdc.202300051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.999 Å)

Structure validation