6Q36

TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A resolution: Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence

Summary for 6Q36

Entry DOI	10.2210/pdb6q36/pdb
Descriptor	Transcriptional enhancer factor TEF-3, ACE-PRO-6CW-ARG-LEU-ARG-LYS-2JH-HYP-ASP-SER-PHE-ALN-LYS-GLU-PRO-NH2, MYRISTIC ACID, ... (5 entities in total)
Functional Keywords	transcription factor, co-activator, transcription regulation, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56145.94
Authors	Kallen, J. (deposition date: 2018-12-03, release date: 2019-07-03, Last modification date: 2024-01-24)
Primary citation	Furet, P.,Salem, B.,Mesrouze, Y.,Schmelzle, T.,Lewis, I.,Kallen, J.,Chene, P. Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence. Bioorg.Med.Chem.Lett., 29:2316-2319, 2019 Cited by PubMed: 31235263 DOI: 10.1016/j.bmcl.2019.06.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation