6Q36
TEAD4(216-434) complexed with optimized peptide 9 and myristoate (covalently bound) at 2.01A resolution: Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-3 | polymer | 220 | 25597.8 | 2 | UniProt (Q15561) Pfam (PF17725) | Homo sapiens (Human) | TEA domain family member 4,TEAD-4,Transcription factor 13-like 1,Transcription factor RTEF-1 |
| 2 | C, D (C, D) | ACE-PRO-6CW-ARG-LEU-ARG-LYS-2JH-HYP-ASP-SER-PHE-ALN-LYS-GLU-PRO-NH2 | polymer | 17 | 2056.8 | 2 | synthetic construct | ||
| 3 | E, H (A, B) | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 4 | F, G, I, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B: 217 - 434 (UniProt: Q15561)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Pro 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55309.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 836.6 | |
| All* | Total formula weight | 56145.9 |
