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3MFH
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BU of 3mfh by Molmil
DNA Polymerase Eta in Complex With Undamaged DNA
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*TP*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ...
著者Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2010-04-02
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the suppression of skin cancers by DNA polymerase eta.
Nature, 465, 2010
3MFI
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BU of 3mfi by Molmil
DNA Polymerase Eta in Complex With a cis-syn Thymidine Dimer
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*(TTD)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ...
著者Silverstein, T.D, Johnson, R.E, Jain, R, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2010-04-02
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural basis for the suppression of skin cancers by DNA polymerase eta.
Nature, 465, 2010
5F9L
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BU of 5f9l by Molmil
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Patra, A, Egli, M.
登録日2015-12-09
公開日2016-12-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta
To Be Published
6PLC
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BU of 6plc by Molmil
Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-06-30
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.
Nucleic Acids Res., 48, 2020
5F9N
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BU of 5f9n by Molmil
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dCMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Patra, A, Egli, M.
登録日2015-12-09
公開日2016-12-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta
To Be Published
7L69
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BU of 7l69 by Molmil
Crystal structure of human polymerase eta complexed with syn N7-benzylguanine
分子名称: DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(7BG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA polymerase eta
著者Jung, H, Lee, S.
登録日2020-12-23
公開日2022-01-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of human polymerase eta complexed with syn N7-benzylguanine
To Be Published
4DL7
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BU of 4dl7 by Molmil
Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (Pt-GG4).
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*TP*AP*CP*TP*CP*GP*GP*TP*CP*AP*CP*T)-3'), ...
著者Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W.
登録日2012-02-05
公開日2012-05-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta
Proc.Natl.Acad.Sci.USA, 109, 2012
2I5O
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BU of 2i5o by Molmil
Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta
分子名称: DNA polymerase eta, ZINC ION
著者Zhou, P, Bomar, M.G.
登録日2006-08-25
公開日2007-03-13
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
Embo Rep., 8, 2007
6MQ8
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BU of 6mq8 by Molmil
Binary structure of DNA polymerase eta in complex with templating hypoxanthine
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*IP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Hawkins, M.A, Jung, H, Lee, S.
登録日2018-10-09
公開日2019-10-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.969 Å)
主引用文献Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Biochem.J., 2020
6D0Z
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BU of 6d0z by Molmil
Polymerase Eta cytarabine (AraC) extension ternary complex
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2018-04-11
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
6PL8
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BU of 6pl8 by Molmil
Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-06-30
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Structure of human DNA polymerase eta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP
To Be Published
6D0M
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BU of 6d0m by Molmil
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2018-04-10
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.832 Å)
主引用文献Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
6PL7
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BU of 6pl7 by Molmil
Structure of human DNA polymerase eta complexed with A in the template base paired with incoming non-hydrolyzable TTP
分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*AP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-06-30
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of human DNA polymerase eta complexed with A in the template base paired with incoming non-hydrolyzable TTP
To Be Published
6W5X
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BU of 6w5x by Molmil
Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(DRG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2020-03-14
公開日2021-03-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
To Be Published
6Q02
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BU of 6q02 by Molmil
Polymerase Eta-catalyzed insertion of the mismatched A opposite template cytarabine (AraC) residue
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primer Strand, DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2019-08-01
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
6PZ3
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BU of 6pz3 by Molmil
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA Primer strand, DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2019-07-31
公開日2019-11-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.395 Å)
主引用文献Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
3SI8
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BU of 3si8 by Molmil
Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2)
分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, ...
著者Biertumpfel, C, Zhao, Y, Kondo, Y, Ramon-Maiques, S, Gregory, M, Lee, J.Y, Masutani, C, Lehmann, A.R, Hanaoka, F, Yang, W.
登録日2011-06-17
公開日2011-08-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
6UQI
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BU of 6uqi by Molmil
Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2019-10-19
公開日2020-10-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
To Be Published
6WK6
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BU of 6wk6 by Molmil
Crystal structure of human polymerase eta complexed with Xanthine containing DNA
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(3ZO)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2020-04-15
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Biochem.J., 477, 2020
6UI2
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BU of 6ui2 by Molmil
Structure of human DNA polymerase eta complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(FMG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
著者Koag, M.C, Lee, S.
登録日2019-09-30
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase eta.
Molecules, 24, 2019
6V5K
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BU of 6v5k by Molmil
Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*T*(QRV)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ...
著者Jung, H, Lee, S.
登録日2019-12-04
公開日2020-12-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structure of human DNA polymerase eta complexed with N7-nitrogen half-mustard guanine (NHMG) and dCTP*
To Be Published
3TQ1
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BU of 3tq1 by Molmil
Human DNA Polymerase eta in binary complex with DNA
分子名称: DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*TP*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta
著者Ummat, A, Silverstein, T.D, Jain, R, Buku, A, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K.
登録日2011-09-08
公開日2012-02-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.556 Å)
主引用文献Human DNA Polymerase Eta Is Pre-Aligned for dNTP Binding and Catalysis.
J.Mol.Biol., 415, 2012
3WUP
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BU of 3wup by Molmil
Crystal Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Polymerase Eta
分子名称: CHLORIDE ION, DNA polymerase eta, GLYCEROL, ...
著者Suzuki, N, Wakatsuki, S, Kawasaki, S.
登録日2014-05-01
公開日2015-06-17
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
Febs J., 283, 2016
5VTP
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BU of 5vtp by Molmil
X-ray diffraction data of DNA Polymerase Eta (RAD30) of Saccharomyces cerevisiae with a single magnesium bound in absence of DNA and incoming dNTP
分子名称: DNA polymerase eta, MAGNESIUM ION
著者Powers, K.T, Washington, M.T.
登録日2017-05-17
公開日2018-01-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The C-terminal region of translesion synthesis DNA polymerase eta is partially unstructured and has high conformational flexibility.
Nucleic Acids Res., 46, 2018
2LSK
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BU of 2lsk by Molmil
C-terminal domain of human REV1 in complex with DNA-polymerase H (eta)
分子名称: DNA polymerase eta, DNA repair protein REV1
著者Pozhidaeva, A, Pustovalova, Y, Bezsonova, I, Korzhnev, D.
登録日2012-05-01
公開日2012-06-27
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase eta.
Biochemistry, 51, 2012

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