3V4K
| First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G | 分子名称: | CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3G, MAGNESIUM ION, ... | 著者 | Shandilya, S.M.D, Ali, A, Schiffer, C.A. | 登録日 | 2011-12-15 | 公開日 | 2012-01-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. Acs Chem.Biol., 7, 2012
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7UXD
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5CQI
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4ROW
| The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C. | 登録日 | 2014-10-29 | 公開日 | 2014-12-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem., 290, 2015
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5TD5
| Crystal Structure of Human APOBEC3B variant complexed with ssDNA | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(P*TP*TP*CP*AP*T)-3'), ... | 著者 | Shi, K, Banerjee, S, Kurahashi, K, Aihara, H. | 登録日 | 2016-09-16 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.718 Å) | 主引用文献 | Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nat. Struct. Mol. Biol., 24, 2017
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5CQH
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... | 著者 | Shi, K, Kurahashi, K, Aihara, H. | 登録日 | 2015-07-21 | 公開日 | 2015-10-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. J.Biol.Chem., 290, 2015
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6NFL
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G complexed with 2-HP | 分子名称: | 1,2-ETHANEDIOL, 1,3-diazinan-2-one, CHLORIDE ION, ... | 著者 | Shi, K, Orellana, K, Aihara, H. | 登録日 | 2018-12-20 | 公開日 | 2019-12-25 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.731 Å) | 主引用文献 | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B Faseb Bioadv, 2, 2020
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5SXH
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | 分子名称: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | 著者 | Shi, K, Kurahashi, K, Aihara, H. | 登録日 | 2016-08-09 | 公開日 | 2017-12-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Sci Rep, 7, 2017
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4ROV
| The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of full-length APOBEC3G to HIV-1 ssDNA | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Lu, X, Zhang, T, Xu, Z, Liu, S, Zhao, B, Lan, W, Wang, C, Ding, J, Cao, C. | 登録日 | 2014-10-29 | 公開日 | 2014-12-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA J.Biol.Chem., 290, 2015
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6BUX
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6NFK
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G bound to iodide | 分子名称: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IODIDE ION | 著者 | Shi, K, Orellana, K, Aihara, H. | 登録日 | 2018-12-20 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B Faseb Bioadv, 2, 2020
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5CQK
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3B, GLYCEROL, SODIUM ION, ... | 著者 | Shi, K, Kurahashi, K, Aihara, H. | 登録日 | 2015-07-21 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. J.Biol.Chem., 290, 2015
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8FIK
| APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate | 分子名称: | CHLORIDE ION, DNA (5'-D(P*CP*CP*CP*AP*TP*CP*AP*TP*TP*CP*GP*AP*TP*GP*GP*G)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | 登録日 | 2022-12-16 | 公開日 | 2023-09-06 | 最終更新日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | 主引用文献 | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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5SXG
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | 分子名称: | 1,3-PROPANDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IMIDAZOLE, ... | 著者 | Shi, K, Kurahashi, K, Aihara, H. | 登録日 | 2016-08-09 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Sci Rep, 7, 2017
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8FIL
| Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate | 分子名称: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | 登録日 | 2022-12-16 | 公開日 | 2023-09-06 | 最終更新日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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3V4J
| First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G | 分子名称: | 4-[methyl(nitroso)amino]benzene-1,2-diol, DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Shandilya, S.M.D, Ali, A, Schiffer, C.A. | 登録日 | 2011-12-15 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. Acs Chem.Biol., 7, 2012
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5CQD
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5KEG
| Crystal structure of APOBEC3A in complex with a single-stranded DNA | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ... | 著者 | Kouno, T, Hilbert, B.J, Silvas, T, Royer, W.E, Matsuo, H, Schiffer, C.A. | 登録日 | 2016-06-09 | 公開日 | 2017-05-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nat Commun, 8, 2017
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8FIM
| Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate | 分子名称: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | 著者 | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | 登録日 | 2022-12-16 | 公開日 | 2023-09-06 | 最終更新日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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3IR2
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3IQS
| Crystal structure of the anti-viral APOBEC3G catalytic domain | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Holden, L.G, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S. | 登録日 | 2009-08-20 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456, 2008
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3E1U
| The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | 著者 | Holden, L, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S. | 登録日 | 2008-08-04 | 公開日 | 2008-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456, 2008
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8J62
| Cryo-EM structure of APOBEC3G-Vif complex | 分子名称: | APOBEC3G, Core binding factor beta, RNA (5'-R(*CP*GP*GP*UP*UP*GP*AP*UP*UP*GP*UP*UP*UP*UP*AP*AP*CP*AP*A)-3'), ... | 著者 | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | 登録日 | 2023-04-24 | 公開日 | 2023-07-19 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G. Nat Commun, 14, 2023
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2NYT
| The APOBEC2 Crystal Structure and Functional Implications for AID | 分子名称: | Probable C->U-editing enzyme APOBEC-2, ZINC ION | 著者 | Prochnow, C, Bransteitter, R, Klein, M, Goodman, M, Chen, X. | 登録日 | 2006-11-21 | 公開日 | 2007-01-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature, 445, 2007
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6NFM
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