8FIM

Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate

Summary for 8FIM

• Entry DOI: 10.2210/pdb8fim/pdb
• Descriptor: DNA dC->dU-editing enzyme APOBEC-3A, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), INOSITOL HEXAKISPHOSPHATE, ... (7 entities in total)
• Functional Keywords: apobec, apobec3a, a3a, apobec3a e72a mutant, cancer, dna, mutation, cytidine deaminase, hairpin dna, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 55451.81

Authors

Harjes, S.,Jameson, G.B.,Harjes, E.,Filichev, V.V.,Kurup, H.M. (deposition date: 2022-12-16, release date: 2023-09-06)

• Primary citation: Harjes, S.,Kurup, H.M.,Filichev, V.,Harjes, E.,Jameson, G.B.; DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)