8FIM
Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA dC->dU-editing enzyme APOBEC-3A | polymer | 199 | 22983.0 | 2 | UniProt (P31941) Pfam (PF05240) | Homo sapiens (human) | A3A,Phorbolin-1 |
| 2 | C, D (H, C) | DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3') | polymer | 13 | 3934.5 | 2 | Homo sapiens | ||
| 3 | E, I (A, B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 4 | F, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | H (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | L, M, N (A, B, H) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 199 (UniProt: P31941)
| PDB | External Database | Details |
|---|---|---|
| Ala 72 | Glu 72 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 53835.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1616.8 | |
| All* | Total formula weight | 55451.8 |
