PDB: 35 件ウェブページステータス検索Chemie searchBIRD

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1BTE	CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (ACTIVIN RECEPTOR TYPE II) 著者 Greenwald, J, Fischer, W, Vale, W, Choe, S. 登録日 1998-09-01 公開日 1999-02-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. Nat.Struct.Biol., 6, 1999
1ES7	COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS 分子名称: BONE MORPHOGENETIC PROTEIN RECEPTOR IA, BONE MORPHOGENETIC PROTEIN-2 著者 Kirsch, T, Sebald, W, Dreyer, M.K. 登録日 2000-04-07 公開日 2000-10-07 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the BMP-2-BRIA ectodomain complex. Nat.Struct.Biol., 7, 2000
1LX5	Crystal Structure of the BMP7/ActRII Extracellular Domain Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin Type II Receptor, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-4)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Greenwald, J, Groppe, J, Kwiatkowski, W, Choe, S. 登録日 2002-06-04 公開日 2003-04-01 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly Mol.Cell, 11, 2003
1NYU	Crystal Structure of Activin A Bound to the ECD of ActRIIB 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
1NYS	Crystal Structure of Activin A Bound to the ECD of ActRIIB P41 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
1REW	Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor 分子名称: bone morphogenetic protein 2, bone morphogenetic protein receptor type IA 著者 Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. 登録日 2003-11-07 公開日 2004-05-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.863 Å) 主引用文献 Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
1S4Y	Crystal structure of the activin/actrIIb extracellular domain 分子名称: Activin receptor type IIB precursor, Inhibin beta A chain 著者 Greenwald, J, Vega, M.E, Allendorph, G.P, Fischer, W.H, Vale, W, Choe, S, Joint Center for Structural Genomics (JCSG) 登録日 2004-01-19 公開日 2004-08-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors. Mol.Cell, 15, 2004
2GOO	Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, Activin receptor type 2A, Bone morphogenetic protein 2, ... 著者 Allendorph, G.P, Choe, S. 登録日 2006-04-13 公開日 2006-05-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc.Natl.Acad.Sci.Usa, 103, 2006
2HLR	Crystal Structure of the Extracellular Domain of the Type II BMP Receptor 分子名称: Bone morphogenetic protein receptor type-2 著者 Mace, P.D, Cutfield, J.F, Cutfield, S.M. 登録日 2006-07-10 公開日 2006-11-28 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding Biochem.Biophys.Res.Commun., 351, 2006
2HLQ	Crystal Structure of the Extracellular Domain of the Type II BMP Receptor 分子名称: Bone morphogenetic protein receptor type-2 著者 Mace, P.D, Cutfield, J.F, Cutfield, S.M. 登録日 2006-07-09 公開日 2006-11-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding Biochem.Biophys.Res.Commun., 351, 2006
2H64	Crystal structure of a ternary ligand-receptor complex of BMP-2 分子名称: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Mueller, T.D, Sebald, W, Weber, D. 登録日 2006-05-30 公開日 2007-04-10 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
2H62	Crystal structure of a ternary ligand-receptor complex of BMP-2 分子名称: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Mueller, T.D. 登録日 2006-05-30 公開日 2007-04-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
2QJ9	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
2QJA	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
2QJB	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
2PJY	Structural basis for cooperative assembly of the TGF-beta signaling complex 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-3 著者 Groppe, J, Zubieta, C. 登録日 2007-04-16 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol.Cell, 29, 2008
2K3G	NMR structure analysis of a BMP receptor 分子名称: Bone morphogenetic protein receptor type-1A 著者 Klages, J, Kotzsch, A, Mueller, T, Kessler, H. 登録日 2008-05-07 公開日 2008-12-16 最終更新日 2021-10-20 実験手法 SOLUTION NMR 主引用文献 The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding. Biochemistry, 47, 2008
3EVS	Crystal structure of the GDF-5:BMP receptor IB complex. 分子名称: Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 著者 Kotzsch, A, Mueller, T.D. 登録日 2008-10-13 公開日 2009-03-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28, 2009
3KFD	Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-1 著者 Radaev, S, Sun, P.D. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J.Biol.Chem., 285, 2010
3NH7	Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA 分子名称: Antibody fragment Fab AbD1556, heavy chain, light chain, ... 著者 Mueller, T.D, Harth, S, Sebald, W. 登録日 2010-06-14 公開日 2010-10-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity Plos One, 5, 2010
2L5S	Solution structure of the extracellular domain of the TGF-beta type I receptor 分子名称: TGF-beta receptor type-1 著者 Zuniga, J.E, Ilangovan, U, Pardeep, M, Hinck, C, Huang, T. 登録日 2010-11-04 公開日 2011-10-26 実験手法 SOLUTION NMR 主引用文献 The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding J.Mol.Biol., 412, 2011
3QB4	Crystal structure of a TGF-beta ligand-receptor complex 分子名称: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5 著者 Mueller, T.D, Nickel, J, Sebald, W. 登録日 2011-01-12 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 GDF-5 can act as a context-dependent BMP-2 antagonist. Bmc Biol., 13, 2015
4FAO	Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... 著者 Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. 登録日 2012-05-22 公開日 2012-06-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.357 Å) 主引用文献 Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287, 2012
5NHR	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM 分子名称: Activin receptor type-2B, Bimagrumab Fv Light-Chain, Bimagrumab Fv heavy-chain 著者 Rondeau, J.-M. 登録日 2017-03-22 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NGV	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM 分子名称: Activin receptor type-2B, TETRAETHYLENE GLYCOL, anti-human ActRIIB mAb BYM338 heavy-chain, ... 著者 Rondeau, J.-M, Lehmann, S. 登録日 2017-03-20 公開日 2017-11-15 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

 

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