8T7C
 
 | | Crystal structure of human phospholipase C gamma 2 | | 分子名称: | 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION | | 著者 | Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J. | | 登録日 | 2023-06-20 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
To Be Published
|
|
9BCZ
 | | Chicken 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) in complex with calcium and phosphorylated threonine | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Edwards, M.M, Dong, A, Theo-Emegano, N, Seitova, A, Loppnau, P, Leung, R, Li, H, Ilyassov, O, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2024-04-10 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Chicken 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) in complex with calcium and phosphorylated threonine
To be published
|
|
8UQO
 | | PLCb3-Gbg-Gaq complex on membranes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2023-10-24 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8UQN
 | | PLCb3-Gaq complex on membranes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2023-10-24 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EMV
 | | Phospholipase C beta 3 (PLCb3) in solution | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EMW
 | | Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EMX
 | |
7T8T
 | | CryoEM structure of PLCg1 | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION | | 著者 | Endo-Streeter, S, Sondek, J. | | 登録日 | 2021-12-17 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | CryoEM structure of PLCg1
To Be Published
|
|
7Z3J
 | | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Pinotsis, N, Bunney, T.D, Katan, M. | | 登録日 | 2022-03-02 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
|
|
7SQ2
 | | Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ... | | 著者 | Endo-Streeter, S.T, Sondek, J, Harden, T.K. | | 登録日 | 2021-11-04 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex
Science, 330, 2010
|
|
6PMP
 | |
6PBC
 | | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION | | 著者 | Hajicek, N, Sondek, J. | | 登録日 | 2019-06-13 | | 公開日 | 2020-01-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
|
|
6S2A
 | | PI PLC mutant H82A | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase | | 著者 | Eisenreichova, A, Boura, E. | | 登録日 | 2019-06-20 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | PI PLC mutant H82A
To Be Published
|
|
4S3G
 | | Structure of the F249X mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | | 著者 | He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F. | | 登録日 | 2015-01-26 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-08-19 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
|
|
4RV3
 | | Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | | 著者 | He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F. | | 登録日 | 2014-11-24 | | 公開日 | 2015-07-01 | | 最終更新日 | 2018-08-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
|
|
4QJ3
 | | Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Lyon, A.M, Tesmer, J.J.G. | | 登録日 | 2014-06-03 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
|
|
4QJ5
 | | Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Lyon, A.M, Tesmer, J.J.G. | | 登録日 | 2014-06-03 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | | 主引用文献 | Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
|
|
4QJ4
 | | Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Lyon, A.M, Tesmer, J.J.G. | | 登録日 | 2014-06-03 | | 公開日 | 2014-10-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
|
|
4I9J
 | | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC | | 分子名称: | (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, 1-phosphatidylinositol phosphodiesterase, ACETATE ION | | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-12-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
|
|
4I90
 | | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to choline | | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION, ... | | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-12-04 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
|
|
4I9T
 | | Structure of the H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, SULFATE ION, ... | | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-12-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
|
|
4I8Y
 | | Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus | | 分子名称: | 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION | | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-12-04 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
|
|
4I9M
 | | Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus bound to HEPES | | 分子名称: | 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION | | 著者 | Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-12-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
|
|
4GNK
 | |
4F2U
 | | Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus | | 分子名称: | 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION | | 著者 | Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F. | | 登録日 | 2012-05-08 | | 公開日 | 2012-12-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
|
|
