1BDG
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1BG3
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1CZA
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![BU of 1cza by Molmil](/molmil-images/mine/1cza) | MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, ... | 著者 | Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. | 登録日 | 1999-09-01 | 公開日 | 2000-03-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
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1DGK
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![BU of 1dgk by Molmil](/molmil-images/mine/1dgk) | MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, PHOSPHATE ION, ... | 著者 | Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. | 登録日 | 1999-11-24 | 公開日 | 2000-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
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1HKB
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![BU of 1hkb by Molmil](/molmil-images/mine/1hkb) | CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, CALCIUM ION, D-GLUCOSE 6-PHOSPHOTRANSFERASE, ... | 著者 | Aleshin, A.E, Zeng, C, Burenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. | 登録日 | 1997-12-01 | 公開日 | 1998-06-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate. Structure, 6, 1998
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1HKC
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1HKG
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1IG8
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![BU of 1ig8 by Molmil](/molmil-images/mine/1ig8) | Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence | 分子名称: | SULFATE ION, hexokinase PII | 著者 | Kuser, P.R, Krauchenco, S, Antunes, O.A, Polikarpov, I. | 登録日 | 2001-04-17 | 公開日 | 2001-05-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. J.Biol.Chem., 275, 2000
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1QHA
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![BU of 1qha by Molmil](/molmil-images/mine/1qha) | HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Rosano, C, Sabini, E, Deriu, D, Magnani, M, Bolognesi, M. | 登録日 | 1999-05-11 | 公開日 | 1999-11-10 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control. Structure Fold.Des., 7, 1999
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1V4S
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![BU of 1v4s by Molmil](/molmil-images/mine/1v4s) | Crystal structure of human glucokinase | 分子名称: | 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, SODIUM ION, alpha-D-glucopyranose, ... | 著者 | Kamata, K, Mitsuya, M, Nishimura, T, Eiki, J, Nagata, Y. | 登録日 | 2003-11-19 | 公開日 | 2004-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase Structure, 12, 2004
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1V4T
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![BU of 1v4t by Molmil](/molmil-images/mine/1v4t) | Crystal structure of human glucokinase | 分子名称: | SODIUM ION, SULFATE ION, glucokinase isoform 2 | 著者 | Kamata, K, Mitsuya, M, Nishimura, T, Eiki, J, Nagata, Y. | 登録日 | 2003-11-19 | 公開日 | 2004-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase Structure, 12, 2004
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2NZT
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![BU of 2nzt by Molmil](/molmil-images/mine/2nzt) | Crystal structure of human hexokinase II | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, Hexokinase-2, UNKNOWN ATOM OR ION, ... | 著者 | Rabeh, W.M, Zhu, H, Nedyalkova, L, Tempel, W, Wasney, G, Landry, R, Vedadi, M, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2006-11-25 | 公開日 | 2006-12-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation. Biosci.Rep., 38, 2018
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2YHX
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3A0I
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![BU of 3a0i by Molmil](/molmil-images/mine/3a0i) | Human glucokinase in complex with a synthetic activator | 分子名称: | 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide, Glucokinase, SODIUM ION, ... | 著者 | Kamata, K, Mitsuya, M. | 登録日 | 2009-03-19 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators Bioorg.Med.Chem.Lett., 19, 2009
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3B8A
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![BU of 3b8a by Molmil](/molmil-images/mine/3b8a) | Crystal structure of yeast hexokinase PI in complex with glucose | 分子名称: | Hexokinase-1, SULFATE ION, beta-D-glucopyranose | 著者 | Kuser, P, Cupri, F, Bleicher, L, Polikarpov, I. | 登録日 | 2007-10-31 | 公開日 | 2008-02-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised. Proteins, 72, 2008
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3F9M
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![BU of 3f9m by Molmil](/molmil-images/mine/3f9m) | Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap | 分子名称: | 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, Glucokinase, alpha-D-glucopyranose | 著者 | Petit, P, Gluais, L, Lagarde, A, Vuillard, L, Boutin, J.A, Ferry, G. | 登録日 | 2008-11-14 | 公開日 | 2008-12-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
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3FGU
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![BU of 3fgu by Molmil](/molmil-images/mine/3fgu) | Catalytic complex of Human Glucokinase | 分子名称: | Glucokinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Petit, P, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L. | 登録日 | 2008-12-08 | 公開日 | 2009-12-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
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3FR0
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![BU of 3fr0 by Molmil](/molmil-images/mine/3fr0) | Human glucokinase in complex with 2-amino benzamide activator | 分子名称: | 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, SODIUM ION, ... | 著者 | Kamata, K. | 登録日 | 2009-01-08 | 公開日 | 2009-02-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators Bioorg.Med.Chem.Lett., 19, 2009
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3GOI
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![BU of 3goi by Molmil](/molmil-images/mine/3goi) | Human glucokinase in complex with a synthetic activator | 分子名称: | 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, alpha-D-glucopyranose | 著者 | Kamata, K, Mitsuya, M. | 登録日 | 2009-03-19 | 公開日 | 2009-04-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators Bioorg.Med.Chem.Lett., 19, 2009
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3H1V
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![BU of 3h1v by Molmil](/molmil-images/mine/3h1v) | Human glucokinase in complex with a synthetic activator | 分子名称: | 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, Glucokinase, SODIUM ION, ... | 著者 | Kamata, K, Takahashi, K. | 登録日 | 2009-04-14 | 公開日 | 2009-10-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg.Med.Chem., 17, 2009
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3HM8
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![BU of 3hm8 by Molmil](/molmil-images/mine/3hm8) | Crystal structure of the C-terminal Hexokinase domain of human HK3 | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, Hexokinase-3, alpha-D-glucopyranose | 著者 | Nedyalkova, L, Tong, Y, Rabeh, W, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-05-28 | 公開日 | 2009-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the C-terminal Hexokinase domain of human HK3 To be Published
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3ID8
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![BU of 3id8 by Molmil](/molmil-images/mine/3id8) | Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP | 分子名称: | 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, Glucokinase, MAGNESIUM ION, ... | 著者 | Petit, P, Gluais, L, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L. | 登録日 | 2009-07-20 | 公開日 | 2010-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
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3IDH
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![BU of 3idh by Molmil](/molmil-images/mine/3idh) | Human pancreatic glucokinase in complex with glucose | 分子名称: | Glucokinase, POTASSIUM ION, alpha-D-glucopyranose | 著者 | Petit, P, Gluais, L, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L. | 登録日 | 2009-07-21 | 公開日 | 2010-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
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3IMX
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![BU of 3imx by Molmil](/molmil-images/mine/3imx) | Crystal Structure of human glucokinase in complex with a synthetic activator | 分子名称: | (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide, Glucokinase, SODIUM ION, ... | 著者 | Stams, T, Vash, B. | 登録日 | 2009-08-11 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. J.Med.Chem., 52, 2009
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3O08
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![BU of 3o08 by Molmil](/molmil-images/mine/3o08) | Crystal structure of dimeric KlHxk1 in crystal form I | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hexokinase, SULFATE ION | 著者 | Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. | 登録日 | 2010-07-19 | 公開日 | 2010-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION. J.Biol.Chem., 285, 2010
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