3H1V

Human glucokinase in complex with a synthetic activator

Summary for 3H1V

• Entry DOI: 10.2210/pdb3h1v/pdb
• Descriptor: Glucokinase, alpha-D-glucopyranose, 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, ... (5 entities in total)
• Functional Keywords: glucokinase, diabetes, allosteric activator, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 51290.15

Authors

Kamata, K.,Takahashi, K. (deposition date: 2009-04-14, release date: 2009-10-06, Last modification date: 2024-03-20)

• Primary citation: Takahashi, K.,Hashimoto, N.,Nakama, C.,Kamata, K.,Sasaki, K.,Yoshimoto, R.,Ohyama, S.,Hosaka, H.,Maruki, H.,Nagata, Y.,Eiki, J.,Nishimura, T.; The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.; Bioorg.Med.Chem., 17:7042-7051, 2009; PubMed: 19736020; DOI: 10.1016/j.bmc.2009.05.037

Experimental method

X-RAY DIFFRACTION (2.11 Å)