3FR0

Human glucokinase in complex with 2-amino benzamide activator

Summary for 3FR0

Entry DOI	10.2210/pdb3fr0/pdb
Related	1V4S 1V4T 3F9M
Descriptor	Glucokinase, alpha-D-glucopyranose, 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, ... (5 entities in total)
Functional Keywords	hexokinase iv, allosteric enzyme, diabetes, alternative splicing, atp-binding, diabetes mellitus, disease mutation, glycolysis, kinase, nucleotide-binding, polymorphism, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	51528.48
Authors	Kamata, K. (deposition date: 2009-01-08, release date: 2009-02-17, Last modification date: 2023-11-01)
Primary citation	Nishimura, T.,Iino, T.,Mitsuya, M.,Bamba, M.,Watanabe, H.,Tsukahara, D.,Kamata, K.,Sasaki, K.,Ohyama, S.,Hosaka, H.,Futamura, M.,Nagata, Y.,Eiki, J. Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators Bioorg.Med.Chem.Lett., 19:1357-1360, 2009 Cited by PubMed: 19188063 DOI: 10.1016/j.bmcl.2009.01.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation