1BDG

HEXOKINASE FROM SCHISTOSOMA MANSONI COMPLEXED WITH GLUCOSE

Summary for 1BDG

Entry DOI	10.2210/pdb1bdg/pdb
Descriptor	HEXOKINASE, alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total)
Functional Keywords	hexokinase, phosphotransferase
Biological source	Schistosoma mansoni
Total number of polymer chains	1
Total formula weight	50979.27
Authors	Mulichak, A.M.,Garavito, R.M. (deposition date: 1998-05-08, release date: 1999-05-11, Last modification date: 2024-10-16)
Primary citation	Mulichak, A.M.,Wilson, J.E.,Padmanabhan, K.,Garavito, R.M. The structure of mammalian hexokinase-1. Nat.Struct.Biol., 5:555-560, 1998 Cited by PubMed Abstract: We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane. PubMed: 9665168 DOI: 10.1038/811 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation