3IMX

Crystal Structure of human glucokinase in complex with a synthetic activator

Summary for 3IMX

Entry DOI	10.2210/pdb3imx/pdb
Descriptor	Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide, ... (5 entities in total)
Functional Keywords	sugar kinase, atp-binding, glycolysis, kinase, nucleotide-binding, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	51655.64
Authors	Stams, T.,Vash, B. (deposition date: 2009-08-11, release date: 2009-10-06, Last modification date: 2023-09-06)
Primary citation	Bebernitz, G.R.,Beaulieu, V.,Dale, B.A.,Deacon, R.,Duttaroy, A.,Gao, J.,Grondine, M.S.,Gupta, R.C.,Kakmak, M.,Kavana, M.,Kirman, L.C.,Liang, J.,Maniara, W.M.,Munshi, S.,Nadkarni, S.S.,Schuster, H.F.,Stams, T.,St Denny, I.,Taslimi, P.M.,Vash, B.,Caplan, S.L. Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. J.Med.Chem., 52:6142-6152, 2009 Cited by PubMed: 19746978 DOI: 10.1021/jm900839k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation