3IMX
Crystal Structure of human glucokinase in complex with a synthetic activator
Summary for 3IMX
Entry DOI | 10.2210/pdb3imx/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide, ... (5 entities in total) |
Functional Keywords | sugar kinase, atp-binding, glycolysis, kinase, nucleotide-binding, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 51655.64 |
Authors | |
Primary citation | Bebernitz, G.R.,Beaulieu, V.,Dale, B.A.,Deacon, R.,Duttaroy, A.,Gao, J.,Grondine, M.S.,Gupta, R.C.,Kakmak, M.,Kavana, M.,Kirman, L.C.,Liang, J.,Maniara, W.M.,Munshi, S.,Nadkarni, S.S.,Schuster, H.F.,Stams, T.,St Denny, I.,Taslimi, P.M.,Vash, B.,Caplan, S.L. Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. J.Med.Chem., 52:6142-6152, 2009 Cited by PubMed: 19746978DOI: 10.1021/jm900839k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report